文献类型：期刊文献

英文题名：The efficacy of Da Chaihu decoction combined with metformin tablets for type 2 diabetes mellitus: A systematic review and meta-analysis

作者：Wang, Jia-bin[1];Wang, Yan-xia[2];Li, Fen[3];Li, Yan-fei[4];Li, Xing-li[5];Huang, Pei-yao[6];Wang, Chen[2];Wang, Meng[7];Qiu, Jie[1,10];Yang, Ke-hu[4];Liu, Lu[9];Mao, Bao-hong[2];Li, Hong-pu[8];Liu, Xu-dong[2];Li, Fu-yun[2];Cui, Xu-dong[7];Wang, Peng-ju[7];Liu, Wen-bo[1]

第一作者：Wang, Jia-bin

通信作者：Qiu, J[1]

机构：[1]Gansu Prov Maternal & Children Hlth Care Hosp, Lanzhou, Peoples R China;[2]Gansu Prov Maternal & Children Hlth Care Hosp, Sci Res Ctr, Lanzhou 730050, Peoples R China;[3]Second Peoples Hosp Qingyang City, Qingyang 745000, Peoples R China;[4]Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou 730000, Peoples R China;[5]Sichuan Prov Maternal & Children Hlth Care Hosp, Chengdu, Peoples R China;[6]Lanzhou Univ, Affiliated Hosp 1, Lanzhou, Peoples R China;[7]Lanzhou Univ, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[8]Xinjiang Med Univ, Clin Med Coll 4, Urumqi 830000, Peoples R China;[9]Gansu Univ Chinese Med, Lanzhou 730000, Peoples R China;[10]Gansu Prov Maternal & Children Hlth Care Hosp, Lanzhou 730000, Peoples R China

第一机构：Gansu Prov Maternal & Children Hlth Care Hosp, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Maternal & Children Hlth Care Hosp, Lanzhou 730000, Peoples R China.

年份：2022

卷号：71

外文期刊名：COMPLEMENTARY THERAPIES IN MEDICINE

收录：;Scopus(收录号：2-s2.0-85140333213);WOS:【SCI-EXPANDED(收录号:WOS:000878773400002)】；

语种：英文

外文关键词：Da Chaihu decoction; Metformin tablets; Type 2 diabetes mellitus; Meta-analysis

摘要：Objective: To assess the efficacy of Da Chaihu decoction combined with metformin tablets on patients with type 2 diabetes compared with metformin alone.Methods: This systematic review and meta-analysis is written based on 2020 PRISMA Extension for Chinese Herbal Medicines 2020 (PRISMA-CHM 2020) reporting guidelines. We reviewed all the relevant studies from a search of the following databases from inception to February 2022 without any language restriction: Excerpta Medica Database (EMBASE), Google Scholar, PubMed, Cochrane Library, China National Knowledge Infra-structure (CNKI), VIP Information, Wanfang Data, and the Chinese Biomedical Literature Database(CBM). Data were extracted and the quality was independently evaluated by two reviewers, based on the inclusion and exclusion criteria. Data were analyzed using the Cochrane software RevMan 5.3.Results: Six randomized controlled trials comprising 516 participants were included. The meta-analysis revealed the Da Chaihu decoction combined with metformin tablets group was significantly superior to the metformin tablets group in terms of fasting blood glucose(FPG) (-0.66 mmol/L; 95 % CI (con-fidence intervals) [-1.28, -0.04]), plasma glucose 2 h after meal (2-h PG) (-1.18 mmol/L; 95 % CI [-1.94,-0.42]) in six RCTs, body mass index (BMI) (-3.07 mmol/L; 95 % CI [-6.89, 0.75]) in three RCTs, glycosylated hemoglobin (HbAlc) (-0.36 mmol/L; 95 % CI [-1.04, 0.31]) in three RCTs, and triglycerides (TG) (-0.76 mmol/L; 95 % CI [-1.37,-0.15]) in two RCTs. In two RCTs, there were significant differences in terms of total cholesterol (TC) (-0.97 mmol/L; 95 % CI [-1.18,-0.76]). Conclusions: Very low-quality research shows that Da Chaihu decoction combined with metformin tablets exert a certain level of efficacy on patients with type 2 diabetes compared with metformin alone. However, random sequence generation methodology was reported in five studies leading to the low quality of the included studies. None of the six studies depicted the blinding method, allocation concealment, selective reporting, and assessed the purity and potency of the product. This observation requires verification through high-quality, multi-center, double-blinded randomized controlled trials, and assesses the purity and potency of the product.