文献类型：期刊文献

中文题名：中医药干预RA性骨病中Wnt/β-catenin信号通路的研究进展

英文题名：Research Progress of Traditional Chinese Medicine in The Intervention of RA Bone Disease Based on Wnt/β-catenin Signaling Pathway

作者：王钢[1];周孟茹[2];李平顺[3];马鹏程[3]

第一作者：王钢

机构：[1]甘肃中医药大学附属医院风湿骨病科,兰州730000;[2]兰州大学基础医学院,兰州730000;[3]甘肃中医药大学,兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2021

卷号：27

期号：6

起止页码：1041

中文期刊名：中国中医基础医学杂志

外文期刊名：JOURNAL OF BASIC CHINESE MEDICINE

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD_E2021_2022】；

基金：国家自然科学基金资助项目(81860858)-基于骨免疫探讨补肾通络法对类风湿关节炎骨破坏及Treg/Th17的影响及机制研究;甘肃省卫生行业科研管理项目(GSWSKY-2014-36)-基于抗CCP抗体和RF的血清水平来探讨类风湿关节炎诊断及骨侵蚀的研究;甘肃中医药大学附属医院创新基金项目(gsfy-2018-02)-基于RANKL-RANK-OPG信号通路探讨补肾通络方对CIA大鼠骨破坏及相关因子的影响。

语种：中文

中文关键词：RA性骨病;Wnt/β-catenin信号通路;中医药;

外文关键词：RA Bone Disease;Wnt/β-catenin Signal Pathway;Traditional Chinese Medicine;

摘要：类风湿性关节炎(rheumatoid arthritis,RA)性骨病是类风湿关节炎疾病进程中造成患者关节功能丧失、心理障碍、经济负担过重等诸多临床问题的主要原因,尚无有效的干预手段。临床与实验研究发现,中医药可通过激活Wnt/β-catenin信号通路干预RA性骨病的发生发展,具体机制可能是通过上调或者下调其过程中的蛋白、因子的转录,从而影响OB、OC的发育、分化,促进骨基质的形成和矿化,抑制骨侵蚀,促进骨重塑。因此,Wnt/β-catenin信号通路为中医药干预RA性骨病提供了靶点与思路,但基础研究与分子生物学方面尚有不足,故就中医药基于Wnt/β-catenin信号通路干预RA性骨病的分子机制进行述评,以期为临床防治RA性骨病提供理论依据。
RA bone disease is the main cause of many clinical problems such as loss of joint function,psychological disorder,and economic burden in the process of rheumatoid arthritis.There is no effective intervention.Clinical and experimental studies have found that TCM can interfere with the development of RA bone disease by activating Wnt/β-catenin signaling pathway.The specific mechanism may be to up-regulate or down-regulate the transcription of proteins and factors in the process,thereby affecting OB and OC,promoting the formation and mineralization of bone matrix,inhibit bone erosion and promote bone remodeling.Therefore,the Wnt/β-catenin signaling pathway provides a target and idea for the intervention of traditional Chinese medicine in RA bone disease,but there are still some shortcomings in basic research and molecular biology.The article deals with RA based on Wnt/β-catenin signaling pathway.The molecular mechanism of osteodystrophy is reviewed in order to provide a theoretical basis for clinical prevention and treatment of RA bone disease.