文献类型：期刊文献

中文题名：近20年心病中药用药规律研究及Logistic回归分析

英文题名：Study on traditional Chinese Medicine prescriptions for cardiovascular diseases over the past 20 years and logistic regression analysis

作者：田茸[1,2];陈丽[1];杨延婷[1];李萍[1]

第一作者：田茸

机构：[1]甘肃中医学院,甘肃兰州730000;[2]上海中医药大学,上海201203

第一机构：甘肃中医药大学

年份：2012

卷号：37

期号：4

起止页码：541

中文期刊名：中国中药杂志

外文期刊名：China Journal of Chinese Materia Medica

收录：MEDLINE(收录号：22667160);CSTPCD;;Scopus;北大核心:【北大核心2011】；CSCD:【CSCD2011_2012】；PubMed;

语种：中文

中文关键词：中药;心病;规律性;Logistic回归分析

外文关键词：traditional Chinese medicine;anti-cardiac effects;regularity;logistic regression

摘要：目的:以中药治疗心病的现代医学研究文献为基础,分析中药特征与心病治疗的相关性并建立相应数学模型,以期为中药治疗心病的实验研究及临床用药提供参考。方法:收集、筛选近20年国内公开发表的中药治疗心病研究的文献,统计检索结果中不同功效、药性、药味、归经的中药数量及其中具有心病治疗作用的中药味数;并用多元判别分析建立回归数学模型。结果:活血化瘀药(21.21%)、补虚药(17.65%)、归心经药(21.82%)、归脾经药(16.11%)在心病治疗研究方面比较活跃,具有显著性差异(P<0.05);采用逐步Logistic回归筛选主要的影响因素,显示归心、脾、胆、心包经的中药和补虚药均是对心病具有治疗作用的重要影响因素(回归系数>0且P<0.05),多元判别分析预测结果与原判定结果总符合率为91.6%,结果与中医学有关理论相吻合。结论:为了有利于人们更为客观地认识中药性味等特征对其心病治疗作用的影响,建立起客观的、回顾性检验正确率更高的Logistic回归方程,建议进一步加强对药典所收录更多中药开展有关心病治疗方面的实验及临床比较研究。
Objective:To analyze the relationship between TCM's characteristics and treatment of cardiovascular diseases on the basis of the modern medical research literatures about treatment of cardiovascular diseases and establish a mathematic model in order to give reference for clinical study and clinical prescription for treatment of cardiovascular diseases with TCMs.Method:Articles on treatment of cardiovascular diseases with TCMs published at home in the past 20 years were collected and screened to summarize the number of TCMs with different function,property,flavor,channel tropism and the number of them with the therapeutically effect on cardiovascular diseases.And a mathematic model was established on the multivariate discriminatory analysis.Result:Medicines for activating blood circulation and removing blood stasis(21.21%),those restoring deficiency(17.65%),those attributive to heart channel(21.82%) and those attributive to spleen channel(16.11%) were relatively active in study for treatment of cardiovascular diseases and showed great difference(P<0.05).According to findings of the logistic regression screen,TCMs attribute to heart,spleen,gallbladder,pericardium channel and those restoring deficiency were important impact factors with therapeutically effect on cardiovascular diseases(regression coefficient>0 and P<0.05).The coincidence was 91.6% between mathematical computing and original classification,indicating the coincidence with relevant theories of the traditional Chinese medical science.Conclusion:A more objective Logistic regression equation with a higher accuracy rate of retrospective inspection is established to detect the effect of TCMs with different characteristics on cardiovascular diseases.It is suggested that more experiments and clinical comparative studies on treatment of cardiovascular diseases with TMCs shall be included in pharmacopeia.