文献类型：期刊文献

中文题名：基于酵母发酵致孔的小麦麸质蛋白/聚丙烯酸钠复合多孔水凝胶的合成及溶胀性能

英文题名：Synthesis,characterization,and swelling behaviors of wheat gluten/poly(sodium acrylate) porous composite hydrogel produced by yeast fermentation

作者：施小宁[1,2];陈晖[2];张浩波[2];戴红霞[2];段国建[2]

第一作者：施小宁

通信作者：Shi, Xiaoning

机构：[1]甘肃省中医药大学甘肃省中药质量与标准研究重点实验室;[2]甘肃中医药大学药学院

第一机构：甘肃省中医药大学甘肃省中药质量与标准研究重点实验室

年份：2018

卷号：35

期号：6

起止页码：1386

中文期刊名：复合材料学报

外文期刊名：Acta Materiae Compositae Sinica

收录：CSTPCD;;EI(收录号：20184105919604);Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2017_2018】；

基金：甘肃省中药质量与标准研究重点实验室培育基地开放基金(ZYZL16-011);甘肃省科技计划资助项目(148RJZA074);甘肃中医药大学中青年基金(2305016601)

语种：中文

中文关键词：小麦麸质蛋白;酵母发酵;多孔水凝胶;盐敏感;pH敏感

外文关键词：wheat gluten;yeast fermentation;porous hydrogel;salt sensitive;pH sensitive

摘要：以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDC)活化丙烯酸(AA)羧基与小麦麸质蛋白(WG)接枝交联,酵母菌素分解WG中淀粉等多糖产生的CO2作为孔模板,水溶液中自由基聚合制备了WG/聚丙烯酸钠(PNaA)多孔复合水凝胶(WG/PNaA)。FTIR分析表明,WG链上—OH、—NH2等与AA成功接枝,并与中和的丙烯酸钠(NaA)在N,N′-亚甲基双丙烯酰胺(MBA)存在下聚合交联。场发射SEM(FESEM)证实,适量酵母菌素在WG体系中产生的CO2可作为孔模板,在WG/PNaA网络中形成蜂窝状多孔结构,这种孔状结构不仅提高了WG/PNaA复合水凝胶在蒸馏水和生理盐水中的平衡溶胀倍率,也使其Schott’s准二级动力学起始溶胀速率常数Kis提高至无酵母致孔样的5倍,Ritger半经验方程分析也证实其扩散系数n=0.5642,为non-Fickian溶胀,即孔状网络在凝胶溶胀初期有利于水分子快速扩散。考察了WG/PNaA复合水凝胶在蒸馏水-生理盐水、pH为2.2和7.4时磷酸缓冲溶液中的溶胀敏感性。结果表明,经过5次反复溶胀-去溶胀循环后仍具有良好的响应性,即多孔WG/PNaA复合凝胶同时具有灵敏可逆的盐和pH敏感性,为该水凝胶在药物控释领域应用提供了潜在可能。
Wheat gluten（WG）reacted with acrylic acid（AA）in the promotion of 1-（3-Dimethylaminopropyl）^-3-ethylcarbodiimide hydrochloride（EDC）to produce WG-AA chains.Following,yeast decomposed the starch that existed in WG to produce CO2,which used as pore template to prepare a novel porous WG/poly（sodium acrylic）（PNaA）composite hydrogel（WG/PNaA）via free-radical graft copolymerization of sodium acrylate and WG-AA chains in the aqueous solution.FTIR spectra demonstrate that AA is grafted onto the WG chains,and the composite hydrogel is formed successfully in the presence of cross-linker N,N′-methylene discrylamide（MBA）.Field emission SEM（FESEM）also displays that incorporating the proper amount of yeast into the hydrogel matrix can form porous interlinked channels within the composite hydrogel network.The porous WG/PNaA composite hydrogel shows greater equilibrium swelling capacity both in distilled water and in 0.9% NaCl solution,and the Schott＇s second-order swelling dynamic constant Kisis improved to 5 times compared with non-yeast exited hydrogel.Ritger＇s semiempirical equation analysis also confirms that the water transport mechanism of the porous WG/PNaA compositehydrogel is non-Fickian diffusion type（n=0.5642）,which means,the porous structure of the composite hydrogel is benefit to the water molecules spread quickly at the beginning swelling.The swelling-deswelling behaviors of the porous WG/PNaA composite hydrogel in distilled water-0.9% NaCl solution and in pH 2.2 and pH 7.4 phosphate buffer solution were assessed and the results show that the composite hydrogel exhibits excellent salt,pH-dependent swelling responsiveness after 5 times repeated swelling,which providing apotential application in the field of drug controlled-release.