文献类型：期刊文献

中文题名：乳酸脱氢酶A在消化系统肿瘤中的作用及相关药物研究进展

英文题名：Research progress of lactate dehydrogenase A in digestive system tumors and related drugs

作者：王思宇[1];李佳蔚[1,2,3];李程豪[1];李玲[1,2];郭晴阳[1];邱璐[1];周世琴[1];刘永琦[1,2]

第一作者：王思宇

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000;[3]甘肃省中医药防治慢性疾病重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：28

期号：4

起止页码：445

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：CSTPCD;;CSCD:【CSCD2023_2024】；

基金：国家自然科学基金资助项目(81960869,82160896);甘肃省自然科学基金(21JR1RA261);甘肃省“双一流”科研重点项目(GSSYLXM-05)。

语种：中文

中文关键词：乳酸脱氢酶A;乳酸代谢;糖酵解;消化系统肿瘤

外文关键词：lactate dehydrogenase A;lactate metabolism;glycolysis;tumors of digestive system

摘要：消化系统恶性肿瘤是严重威胁世界各地人类健康的高发恶性肿瘤,其目前传统治疗方式的疗效及预后尚无法达到预期,因此亟须寻找肿瘤治疗新靶点,实现肿瘤的靶向治疗手段。肿瘤细胞的能量代谢异常被视为癌症的标志,恶性肿瘤细胞通过有氧糖酵解途径摄取葡萄糖,在一系列酶的催化下获取少量能量并生成乳酸。乳酸脱氢酶A(lactate dehydrogenase A,LDHA)作为肿瘤细胞有氧糖酵解途径中的关键酶,在肿瘤细胞的代谢改变中扮演着重要角色,研究证明LDHA在多种肿瘤细胞中具有高表达特性,在临床上其高表达常与肿瘤的预后不良和高转移率有关,有望成为肿瘤治疗新靶点。本文综述了LDHA在消化系统肿瘤发生发展中的作用及其相关药物研究进展。
Malignant tumors of digestive system are highly prevalent malignant tumors that seriously threaten human health around the world.At present,the curative efficacy and prognosis of traditional treatment methods cannot reach the expectation,so it is urgent to find new targets for cancer treatment and realize targeted therapy for tumors.Abnormal energy metabolism in tumor cells is regarded as a hallmark of cancer,and malignant tumor cells absorb glucose through aerobic glycolysis pathway,and obtain a small amount of energy and produce lactate under the catalysis of a series of enzymes.Lactate dehydrogenase A(Lactate dehydrogenase A, LDHA), as a key enzyme inthe aerobic glycolysis pathway of tumor cells, playsan important role in the metabolic changes of tumorcells. Studies have demonstrated that LDHAhas high expression characteristics in a variety oftumor cells,and its high expression in clinic is oftenrelated to the poor prognosis and high metastasisrate of tumors, which is expected to be a new targetfor cancer therapy. This article reviews the roleof LDHA in the development of digestive system tumorsand the research progress of related drugs.