文献类型：期刊文献

中文题名：基于基准关联度和AHP-熵权法的二仙汤醇提工艺研究

英文题名：Optimization of Extraction Process for Erxian Decoction Based on Standard Relation and AHP-Entropy Weight Method

作者：张敏[1,2,3,4];黄雪艳[1,2,3];曾庆祥[1,2,3];武晓玉[1,2,3];刘晓霞[1,2,3];冯晓莉[1,2,3];付文芮[1,2,3];魏舒畅[1,2,3]

第一作者：张敏

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省中药制药工艺工程研究中心,兰州730000;[3]陇药产业创新研究院,兰州730000;[4]甘肃医学院,甘肃平凉744000

第一机构：甘肃中医药大学

年份：2025

卷号：60

期号：8

起止页码：801

中文期刊名：中国药学杂志

外文期刊名：Chinese Pharmaceutical Journal

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金项目资助(8206140176)。

语种：中文

中文关键词：二仙汤;醇提工艺;Box-Behnken响应面法;基准关联度;层次分析法-熵权法

外文关键词：Erxian Decoction;alcohol extraction process;Box-Behnken response surface method;standard relation;AHP-entropy weight method

摘要：目的为保证二仙汤(Erxian Decoction,EXD)传统汤剂和醇提工艺的质量一致性,采用基准关联度和层次分析法(AHP)-熵权法确定权重系数,以Box-Behnken响应面法优选EXD醇提工艺,为现代制剂研究奠定基础。方法以黄柏碱、芒果苷、阿魏酸、小檗碱、仙茅苷、朝藿定A1,朝藿定A,朝藿定B,朝藿定C,淫羊藿苷含量、出膏率、指纹图谱相似度作为关键质量因素,以乙醇体积分数、料液比、提取时间为关键工艺参数,结合Box-Behnken响应面法得到最佳提取工艺并验证。结果确定EXD醇提工艺的最佳条件为乙醇体积分数75%,料液比1∶14(g∶mL),提取时间62 min。验证实验结果表明,综合评分均值86.64,相对标准差(RSD)为1.02%。结论基准关联度结合AHP-熵权法优化EXD进行醇提工艺,所拟合的模型显著,与基准汤剂质量一致度高,为后期剂型更改提供参考。
OBJECTIVE To ensure the equivalence of the ancient and modern processes,and optimize the alcohol extractionprocess of Erxian Decoction(EXD),using standard relation andanalytic hierarchy process(AHP)-entropy weight method combinedwith Box-Behnken response surface method.METHODS Taking phellodendrine,mangiferin,ferulic acid,berberine,curculigoside,epmedin A1,epmedin A,epmedin B,epmedin C,icariin content,dry extract rate and fingerprint similarity as the key quality factors,taking ethanol concetration,solid-liquid ratio and extraction time as the key process parameters,the best extraction process was obtained by Box-Behnken response surface method.RESULTS The optimal conditions were 75%ethanol,1∶14 solid-liquid ratio(g∶mL)and 62 min extraction time.The verified experimental results showed that the average comprehensive score was 86.64,and the relative standard deviation(RSD)was 1.02%.CONCLUSION The alcohol extraction process of EXD is optimized using standard relation combined with AHP-entropy weight method,the fitted model is significant,and the quality of the standard decoction is highly consistent,which provids a reference for the change of dosage form in the later stage.