文献类型：期刊文献

英文题名：The regulatory process and practical significance of non-coding RNA in the dissemination of prostate cancer to the skeletal system

作者：Sang, Hui[1];Li, Luxi[1];Zhao, Qiang[1];Liu, Yulin[1];Hu, Jinbo[1];Niu, Peng[1];Hao, Zhenming[1];Chai, Keqiang[1]

第一作者：Sang, Hui

通信作者：Hao, ZM[1];Chai, KQ[1]

机构：[1]Gansu Univ Tradit Chinese Med, Dept Urol, Affiliated Hosp 3, Baiyin, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Dept Urol, Affiliated Hosp 3, Baiyin, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：14

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85189358033);WOS:【SCI-EXPANDED(收录号:WOS:001195971000001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Baiyin Science and Technology Plan Project (Clinical Application research on early screening of Prostate cancer in Baiyin Area: 2022-3-6Y) and Baiyin First People's Hospital Science and Technology Plan Project (2019YK-08).

语种：英文

外文关键词：prostate cancer; bone metastasis; non-coding RNA; micro RNA; long non-coding RNA; circular RNA; signaling pathway; targeted therapy

摘要：Prostate cancer is a major contributor to male cancer-related mortality globally. It has a particular affinity for the skeletal system with metastasis to bones seriously impacting prognosis. The identification of prostate cancer biomarkers can significantly enhance diagnosis and patient monitoring. Research has found that cancer and metastases exhibit abnormal expression of numerous non-coding RNA. Some of these RNA facilitate prostate cancer bone metastasis by activating downstream signaling pathways, while others inhibit this process. Elucidating the functional processes of non-coding RNA in prostate cancer bone metastasis will likely lead to innovative treatment strategies for this malignant condition. In this review, the mechanistic role of the various RNA in prostate cancer is examined. Our goal is to provide a new avenue of approach to the diagnosis and treatment of bone metastasis in this cancer.