文献类型：期刊文献

英文题名：Instant sedative effect of acupuncture at GV20 on the frequency of electroencephalogram a and β waves in a model of sleep deprivation

作者：Li, Jia[1];Ran, Xiao[1];Cui, Chao[1];Xiang, Chao[1];Zhang, Ao[1,2];Shen, Feng[1]

第一作者：Li, Jia

通信作者：Shen, F[1];Zhang, A[2]

机构：[1]Hubei Univ Chinese Med, Coll Acupuncture & Orthopaed, Hubei Prov Collaborat Innovat Ctr Prevent Treatme, 1 Tanhualin Rd, Wuhan 430061, Hubei, Peoples R China;[2]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, 35 Dingxi Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：Hubei Univ Chinese Med, Coll Acupuncture & Orthopaed, Hubei Prov Collaborat Innovat Ctr Prevent Treatme, 1 Tanhualin Rd, Wuhan 430061, Hubei, Peoples R China

通信机构：[1]corresponding author), Hubei Univ Chinese Med, Coll Acupuncture & Orthopaed, Hubei Prov Collaborat Innovat Ctr Prevent Treatme, 1 Tanhualin Rd, Wuhan 430061, Hubei, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, 35 Dingxi Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735db5df93766a96e5b]甘肃中医药大学针灸推拿学院;[10735]甘肃中医药大学;

年份：2018

卷号：15

期号：6

起止页码：5353

外文期刊名：EXPERIMENTAL AND THERAPEUTIC MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000435174400108)】；

基金：The present study was supported by Hubei Province Scientific and Technological Research Projects (grant nos. 20162006 and 2016CFB221).

语种：英文

外文关键词：GV20; acupuncture; insomnia; electroencephalogram; sedative effect

摘要：Sleep deprivation (SD) adversely affects brain function and is accompanied by frequency-dependent changes in electroencephalograms (EEGs). Recent studies have suggested that acupuncture is an emerging alternative therapy for SD. However, the involvement of the frequency of EEG a and beta waves in the protective effect of acupuncture against SD remains unknown. The present study investigated the instant effect of acupuncture at GV20 on insomnia by analyzing the frequency of a and beta waves using electroencephalography in a model of sleep deprivation. A total of 16 rats (Wistar; male; weight, 340 +/- 10 g) were divided randomly into four groups (4 rats per group) to create a rat model of sleep deprivation using the modified multiple platform method in the GV20 group, the sham acupoint group and the model group. After 72 h of sleep deprivation for these three groups and normal feeding for the blank group, the EEG data of all four groups were documented. Following the initial measurement, the GV20 group was treated by acupuncture at GV20 and the sham acupoint group was treated at the sham acupoint, and their EEGs were recorded during the treatment. The frequency of a and beta waves of all EEG data were analyzed. Prior to intervention, the GV20 group, the sham acupoint group and the model group exhibited no significant differences in a and beta wave frequencies; however, the a wave frequency of these three groups was significantly decreased compared with the blank group (P<0.05), whereas the beta wave frequency of these three groups was significantly increased compared with the blank group (P<0.05). This suggested that sleep deprivation affected the frequency of brain waves and enhanced the excitability of the cerebral cortex. During acupuncture treatment with retained needle conditioning, the GV20 group indicated a significant increase in a wave frequency (P<0.05), as well as a significant decrease in beta wave frequency compared with prior to treatment (P<0.05), whereas the sham acupoint group exhibited no significant changes. The present findings from a rat model of sleep deprivation suggested that acupuncture treatment at GV20 may reduce the excitability of the brain cortex. Due to its sedative effect, treatment at GV20 may be considered for the treatment of insomnia and related symptoms.