文献类型：期刊文献

中文题名：中医药治疗干眼的循证证据评价研究

英文题名：Evaluation of the evidence-based medicine of traditional Chinese medicine in the treatment of dry eye

作者：令娟[1,2];韩雪[2];胡梅[2];杨雪[2];李嘉进[2];代明丽[2];庄家园[2];高英[2];胡亦明[2];杨芮[3];康莉[3];雷迅文[3];罗向霞[3]

第一作者：令娟

机构：[1]甘肃省人民医院,甘肃省兰州市730030;[2]甘肃中医药大学中医临床学院,甘肃省兰州市730030;[3]甘肃省中医院,甘肃省兰州市730050

第一机构：甘肃省人民医院,甘肃省兰州市730030

年份：2025

卷号：45

期号：11

起止页码：888

中文期刊名：眼科新进展

外文期刊名：Recent Advances in Ophthalmology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金项目(编号:8236150800);甘肃省自然科学基金项目(编号:24JRRA566);甘肃省省级人才项目[编号:甘组通字(2024)4号];甘肃省高校研究生“创新之星”项目(编号:2025CXZX-911);甘肃省科技计划项目优秀博士生项目(编号:24JRRA614);甘肃省拔尖领军人才项目[编号:省委人才小组发(2024)12号];甘肃省药品监督管理局科研项目(编号:2025GSMPA064);甘肃省名中医罗向霞传承工作室建设项目。

语种：中文

中文关键词：中医药;干眼;循证证据评价

外文关键词：traditional Chinese medicine;dry eye;evaluation of evidence-based evidence

摘要：目的 系统评估中医药治疗干眼的循证医学证据,分析其疗效及与现代西医治疗的差异,为临床应用提供科学依据。方法 通过检索中英文数据库(包括中国知网、万方数据、PubMed、Cochrane Library等),纳入中医药治疗干眼的Meta分析及系统评价文献。按照严格的纳入和排除标准筛选文献,提取相关数据并进行整合分析。采用Mantel-Haenszel固定效应模型计算相对危险度(RR)及均数差(WMD),以95%置信区间表示效应量,分析中医药治疗干眼的疗效指标。结果 最终纳入21篇文献,涉及中医药治疗干眼的多种干预措施(如中药、针灸、中医外治法等)。结果 显示,中医药治疗在提高临床总有效率[RR=1.63,95%CI(1.46,1.81),P<0.05]、延长泪膜破裂时间[MD=2.23,95%CI(1.85,2.60),P<0.05]、增加泪液分泌量[MD=1.49,95%CI(1.04,1.94),P<0.05]等方面均优于单纯西药治疗。此外,针灸、中药联合西药及中医外治法等治疗方式在改善干眼状和泪液功能方面均表现出独特优势。结论 中医药治疗干眼在临床总有效率、泪膜破裂时间、泪液分泌量等关键指标上显示出显著疗效,且安全性较高。
Objective This study aims to systematically evaluate the evidence-based medicine of traditional Chinese medicine(TCM)in the treatment of dry eye,analyze its efficacy and differences compared with modern Western medicine treatments,and provide a scientific basis for clinical application.Methods By searching Chinese and English databases(including CNKI,Wanfang Data,PubMed,Cochrane Library,etc.),we included meta-analyses and systematic reviews of TCM treatments for dry eye.Literature was screened according to strict inclusion and exclusion criteria,and relevant data were extracted and integrated for analysis.The Mantel-Haenszel fixed-effects model was used to calculate the relative risk(RR)and mean difference(WMD),with the effect size expressed as a 95%confidence interval,to analyze the efficacy indicators of TCM treatment for dry eye.Results A total of 21 articles were finally included,involving various TCM interventions for dry eye(such as Chinese herbal medicine,acupuncture,and TCM external therapies).The results showed that TCM treatment was superior to Western medicine alone in improving the overall clinical efficacy[RR=1.63,95%CI(1.46,1.81),P<0.05],prolonging tear film break-up time[MD=2.23,95%CI(1.85,2.60),P<0.05],and increasing tear secretion[MD=1.49,95%CI(1.04,1.94),P<0.05].In addition,acupuncture,the combination of Chinese herbal medicine and Western medicine,and TCM external therapies all demonstrated unique advantages in improving dry eye symptoms and tear function.Conclusion TCM treatment for dry eye shows significant efficacy in key indicators such as overall clinical efficacy,tear film break-up time,and tear secretion,with a high level of safety.