文献类型：期刊文献

中文题名：“态靶结合”理念下中医药调控肠道微生态干预肾纤维化研究概述

英文题名：Intervention of Renal Fibrosis with Traditional Chinese Medicine by Regulating Intestinal Microecology Based on "Combination of State and Target"

作者：李旭萍[1];马海兰[2];马鸿斌[1];魏锦慧[1]

第一作者：李旭萍

机构：[1]甘肃中医药大学附属医院,兰州730020;[2]甘肃中医药大学,兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2023

卷号：29

期号：4

起止页码：185

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；

基金：甘肃省自然科学基金项目(21JR7RA577);甘肃省中医药管理局项目(GZK-2019-30);全国西学中骨干人才培训项目(国中医药人教函[2019]44号)。

语种：中文

中文关键词：态靶结合;肾纤维化;肠道菌群;异病同治;慢性肾脏疾病;中医药

外文关键词：combination of state and target;renal fibrosis;intestinal flora;treatment of different diseases with the same method;chronic kidney disease;traditional Chinese medicine

摘要：肾纤维化是慢性肾脏疾病进展为终末期肾病的主要病理特征,致病因素繁杂、病程迁延难愈,严重影响患者生存质量并伴随沉重医疗负担。当肠道微生物组群失调时,机体内环境稳态被打破,显现出各类“偏态”,而“态靶结合”理念下重建肠道菌群与恢复微生物多样性可为肾纤维化的辨证施治赋予新的科学内涵。此外,中医学“异病同治”原则下中医药靶向干预肠道微生态具有独特优势,可为肾纤维化的诊疗策略提供理论指导,具体包括:(1)重视宏观调态与微观打靶;(2)针对肾纤维化过程中的炎症反应、内毒素积累及细胞外基质(ECM)过度沉积等确立了肾纤维化治湿、治浊毒、治虚瘀的诊疗策略;(3)古籍名方或中药复方、经典方药配伍、中药单体或活性组分靶向干预肠道微生态等。因此,该文将中医学基础理论与现代医学发病机制相结合,以肾系疾病(肾纤维化)共同致病因素或病理产物-肠道微生态失衡为切入点,梳理中医药调控肠道微生态干预肾脏纤维化的研究现状与科学内涵,以期为相关制剂产品开发及更深层次分子生物学研究提供新思路与新方法。
Renal fibrosis is the main pathological foundation of chronic kidney diseases progressing to end-stage renal diseases. With complex pathogenic factors and prolonged disease course, it threatens the quality of life of patients and brings about heavy financial burden to medical care. In the instance of intestinal flora disturbance, the internal homeostasis is broken, resulting in various "imbalances". The "combination of state and target" endows the syndrome differentiation-based treatment of renal fibrosis with new connotation from the perspective of intestinal flora reconstruction and microbial diversity restoration. In addition, traditional Chinese medicine(TCM)-targeted intervention of intestinal microecology has unique advantages under the principle of "treating different diseases with the same method", which can guide the diagnosis and treatment of renal fibrosis.To be specific, TCM emphasizes macroscopic regulation of state and microscopic targeting. In view of the inflammatory response, accumulation of endotoxin, and excessive deposition of extracellular matrix(ECM) in the process of renal fibrosis, the strategies for treating this disease have been developed, such as alleviating dampness,removing turbid toxin, and relieving deficiency and stasis. Famous prescriptions in ancient books or compound Chinese medicine prescriptions, classical formulas, Chinese medicine monomers, or active components of Chinese medicine target intestinal microecology. Therefore, from the perspective of common pathogenic factors of renal diseases(renal fibrosis) or pathological product-intestinal microecological imbalance, this article combines TCM basic theory with modern medical pathogenesis, and summarizes the research on TCM intervention of renal fibrosis by regulating intestinal microecology and the scientific connotation of renal fibrosis, which is expected to provide ideas and methods for the product development and related preparations and in-depth molecular biological research.