文献类型：期刊文献

中文题名：中药单体调控PI3K/Akt/mTOR信号通路治疗骨肉瘤的研究进展

英文题名：Chinese Medicine Monomers in Treatment of Osteosarcoma by Regulating PI3K/Akt/mTOR Signaling Pathway:A Review

作者：杨浩东[1];李宁[1,2];谢兴文[2];丁聚贤[3];柳博[3];刘凯[1]

第一作者：杨浩东

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院,兰州730000;[3]甘肃省第二人民医院,西北民族大学附属医院,兰州1730030

第一机构：甘肃中医药大学

年份：2023

卷号：29

期号：3

起止页码：254

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金项目(82060873);甘肃省自然科学基金项目(20JR10RA326);甘肃省青年科技基金项目(21JR7RA672)。

语种：中文

中文关键词：骨肉瘤;磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)信号通路;中医;中药单体;肿瘤细胞

外文关键词：osteosarcoma;phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/Akt/mTOR)signaling pathway;Chinese medicine;Chinese medicine monomer;tumor cell

摘要：骨肉瘤是临床上常见的一种原发性骨恶性肿瘤,具有肿瘤异质性高,预后差,易发生病变局部侵袭和远处转移及病死率高的特点。新辅助化疗联合保肢术为目前治疗骨肉瘤的主要治疗手段,虽然通过此种治疗方法有效地降低了骨肉瘤患者的致残率和致死率,但随着化疗技术的应用,长时间化疗药物的使用使得骨肉瘤细胞对其产生耐药作用,降低了肿瘤细胞对药物的敏感度,使得此治疗方式具有了一定的局限性。近年来,随着中医药抗肿瘤的发展和进步,中医药以其治疗效果明显,不良反应少等优势受到了广泛的关注。磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路作为经典的癌症信号通路,在骨肉瘤细胞中被异常激活,通过影响肿瘤细胞的周期、抑制肿瘤细胞的凋亡、抑制肿瘤细胞的自噬及促进肿瘤新生血管的生成,影响骨肉瘤细胞的增殖、侵袭和转移等活动。临床研究发现,中药单体可以通过调控PI3K/Akt/mTOR信号通路蛋白的活性,对骨肉瘤细胞的增殖、凋亡、自噬及新生血管的生成等方面产生作用,发挥抑制骨肉瘤组织和细胞发展的作用,并且能高效的逆转肿瘤细胞对抗癌药物的多药耐药。该文将从中医对骨肉瘤的认识和经验积累,及中药单体调控PI3K/Akt/mTOR信号通路在治疗骨肉瘤疾病的研究进展作一综述,以期为中医药治疗骨肉瘤疾病的应用提供参考。
Osteosarcoma,a common primary bone malignancy,features high heterogeneity,poor prognosis,high propensity for local invasion and distant metastasis,and high mortality.At the moment,the major therapy is the combination of neoadjuvant chemotherapy and limb salvage surgery,which remarkably reduces the disability rate and fatality rate.However,long-term use of chemotherapeutic drugs leads to the acquisition of drug resistance by osteosarcoma cells and reduces the sensitivity of the tumor cells to the drugs.Thus,this therapy is not satisfactory.In recent years,amid the advancement in the treatment of tumor,Chinese medicine has attracted extensive attention for the obvious therapeutic effect and few adverse reactions.Phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway,as a classic cancer signaling pathway,is abnormally activated in osteosarcoma cells,which affects the proliferation,invasion,and metastasis of osteosarcoma cells by influencing the cycle of tumor cells,inhibiting apoptosis and autophagy of tumor cells,and promoting tumor angiogenesis.According to clinical research,Chinese medicine monomers influence proliferation,apoptosis,and autophagy of osteosarcoma cells and angiogenesis by regulating the activity of proteins in PI3K/Akt/mTOR signaling pathway,thereby suppressing osteosarcoma tissues and cells.Moreover,they can reverse the resistance of tumor cells to multiple anticancer drugs.Based on the knowledge and experience of Chinese medicine in the treatment of osteosarcoma,this paper reviews the role of PI3K/Akt/mTOR signaling pathway in the treatment of osteosarcoma by Chinese medicine monomers,which is expected to serve as a reference for the application of Chinese medicine in the treatment of osteosarcoma.