文献类型：期刊文献

英文题名：Energy metabolism: A critical target of cardiovascular injury

作者：Li, Qiyang[1];Zhang, Shangzu[1];Yang, Gengqiang[1];Wang, Xin[1];Liu, Fuxian[1];Li, Yangyang[1];Chen, Yan[1];Zhou, Ting[1];Xie, Dingxiong[2];Liu, Yongqi[1,3];Zhang, Liying[1,2]

第一作者：Li, Qiyang

通信作者：Liu, YQ[1];Zhang, LY[1];Xie, DX[2];Zhang, LY[2]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou, Peoples R China;[2]Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China;[3]Minist Educ, Key Lab Dunhuang Med & Transformat, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou, Peoples R China;[2]corresponding author), Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：165

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：;Scopus(收录号：2-s2.0-85166676901);WOS:【SCI-EXPANDED(收录号:WOS:001052211800001)】；

基金：The authors' work was supported by the Chinese Postdoctoral Science Foundation (No. 2021M693794 to Liying Zhang), Provincial University industry support project in Gansu (No. 0.2020C-15 to Yongqi Liu), the National Natural Science Foundation of China (No. 82004094, and No. 82260882), Major Scientific and Technological Projects in Gansu Province (NO. 22ZD1FA001) in part by 2022 Pharmaceutical Research Projects (No. 2022GSMPA002 to Liying Zhang).

语种：英文

外文关键词：Energy metabolism; Ischemic heart disease; Heart failure; Mitochondrion; Diabetic cardiomyopathy; Ischemia; reperfusion injury

摘要：Cardiovascular diseases are the main killers threatening human health. Many studies have shown that abnormal energy metabolism plays a key role in the occurrence and development of acute and chronic cardiovascular diseases. Regulating cardiac energy metabolism is a frontier topic in the treatment of cardiovascular diseases. However, we are not very clear about the choice of different substrates, the specific mechanism of energy metabolism participating in the course of cardiovascular disease, and how to develop appropriate drugs to regulate energy metabolism to treat cardiovascular disease. Therefore, this paper reviews how energy meta-bolism participates in cardiovascular pathophysiological processes and potential drugs aimed at interfering energy metabolism.It is expected to provide good suggestions for promoting the clinical prevention and treat-ment of cardiovascular diseases from the perspective of energy metabolism.