文献类型：期刊文献

英文题名：Comprehensive Analysis of Potential Common Pathogenic Mechanisms for COVID-19 Infection and Gastric Cancer

作者：Zhang, Guiqian[1];Wang, Ning[2];Ma, Shixun[3,4,5];Zhang, Yan[3,4,5];Tao, Pengxian[3,4,6];Cai, Hui[3,4,5]

第一作者：Zhang, Guiqian

通信作者：Tao, PX[1];Cai, H[1];Tao, PX[2];Cai, H[2];Cai, H[3];Tao, PX[4]

机构：[1]940th Hosp Joint Logist Support Force Peoples Libe, Otorhinolaryngol Head & Neck Surg, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Peoples R China;[4]Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou, Peoples R China;[5]Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Peoples R China;[6]Gansu Prov Hosp, Cadre Ward Gen Surg Dept, Lanzhou, Peoples R China

第一机构：940th Hosp Joint Logist Support Force Peoples Libe, Otorhinolaryngol Head & Neck Surg, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou, Peoples R China;[3]corresponding author), Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Peoples R China;[4]corresponding author), Gansu Prov Hosp, Cadre Ward Gen Surg Dept, Lanzhou, Peoples R China.

年份：2025

卷号：2025

期号：1

外文期刊名：ANALYTICAL CELLULAR PATHOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001441116900001)】；

基金：We would like to thank Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province and General Surgery Clinical Medical Center of Gansu Provincial Hospital for their contributions.

语种：英文

外文关键词：COVID-19 pneumonia; differentially expressed genes; gastric cancer; hub genes; pathogenesis

摘要：A growing body of data suggests that the prevalence of COVID-19 pneumonia in patients with stomach cancer is much higher than in the general population. However, these mechanisms are still not fully understood. After a thorough examination of shared differentially expressed genes (DEGs) for gastric cancer (GC) and COVID-19 pneumonia, we performed functional annotation, protein-protein interaction (PPI) networks, module design, and pivot gene identification. qPCR was used to verify the expression of hub genes in GC. Finally, a pivotal gene transcription factor-gene regulatory network was created and validated. According to functional enrichment analysis, common genes are mainly enriched in biological processes such as extracellular matrix tissue and extracellular structural tissue. Finally, five genes were found to be pivotal genes in the pathogenesis of GC and COVID-19 pneumonia: BGN (biglycan), UBE2C (ubiquitin-conjugating enzymes 2C), SPP1 (secreted phosphoprotein 1), THBS2 (thrombospondin 2), and COL1A1 (type I collagen alpha 1). These shared pathways and pivotal genes could provide new insights for more mechanistic studies.