详细信息
二甲双胍改善糖尿病视网膜病变机制研究进展 被引量:16
Research progress on the mechanism of metformin in improving diabetic retinopathy
文献类型:期刊文献
中文题名:二甲双胍改善糖尿病视网膜病变机制研究进展
英文题名:Research progress on the mechanism of metformin in improving diabetic retinopathy
作者:苏萌[1];白惠玲[2];孔宝焕[3];李正红[3];刘勤[2]
第一作者:苏萌
机构:[1]甘肃中医药大学临床医学院,甘肃兰州730000;[2]甘肃省人民医院眼科,甘肃兰州730000;[3]临夏州人民医院眼科,甘肃临夏731100
第一机构:甘肃中医药大学临床医学院
年份:2019
卷号:35
期号:14
起止页码:1530
中文期刊名:中国临床药理学杂志
外文期刊名:The Chinese Journal of Clinical Pharmacology
收录:CSTPCD;;北大核心:【北大核心2017】;CSCD:【CSCD2019_2020】;
基金:甘肃省科技厅科研基金资助项目(18JR3RA049);甘肃中医药大学研究生创新基金资助项目(2019CX32)
语种:中文
中文关键词:二甲双胍;糖尿病;糖尿病视网膜病
外文关键词:metformin;diabetes mellitus;diabetic retinopathy
摘要:二甲双胍是目前全世界应用最广泛的一种降糖药物,可以降低血糖、调节血脂、改善胰岛素敏感性和预防糖尿病进展。研究表明,二甲双胍还可改善糖尿病视网膜病变的眼底病变情况,并延缓糖尿病相关的血管并发症的发生发展,已经并且正在进行大量的体外和体内研究以及临床试验。糖尿病视网膜病变是最常见的糖尿病微血管并发症之一。近年来,该疾病的发病率增加,因此早期诊断和治疗非常重要。本文对近年来二甲双胍与糖尿病视网膜病变相关的研究进展加以综述。
Metformin is the most widely used hypoglycemic drug in the world,which can reduce blood glucose,regulate blood lipids,improve insulin sensitivity and prevent the progress of diabetes. At the same time,metformin can also improve the fundus of diabetic retinopathy and delay the occurrence and development of diabetes-related vascular complications. A large number of in vitro and in vivo studies and clinical trials have been and are being carried out. Diabetic retinopathy is one of the most common diabetic microvascular complications. In recent years,the incidence of the disease has increased,so early diagnosis and treatment is very important. This paper will review the research progress of metformin related to diabetic retinopathy in recent years.
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