文献类型：期刊文献

英文题名：Parathyroid hormone mediates the adverse impact of air pollution exposure on serum 25-hydroxyvitamin D: A nationwide cross-sectional study in China

作者：Zhang, Haitao[1,2,3,7];Wang, Jing[2,4];Meng, Xia[5,6];Shu, Bing[2,3,7];Yuan, Chunchun[1,2,3,7];Xie, Xingwen[8];Liao, Zhangyu[9];Jiang, Xiaobing[10];Chen, Bolai[11];Lin, Xinchao[12];Wei, Xu[13];Leng, Xiangyang[14];Lu, Sheng[1,2,3];Shi, Qi[1,2,3,7];Kan, Haidong[5,6];Tang, Dezhi[1,2,3];Cai, Jing[5,6];Wang, Yongjun[1,2,3,7]

第一作者：Zhang, Haitao

通信作者：Tang, DZ[1];Wang, YJ[1];Cai, J[2];Cai, J[3]

机构：[1]Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China;[2]Minist Educ, Key Lab Theory & Therapy Muscles & Bones, Shanghai 201203, Peoples R China;[3]Shanghai Acad Tradit Chinese Med, Spine Inst, Shanghai 201203, Peoples R China;[4]Shanghai Geriatr Inst Chinese Med, Shanghai 201203, Peoples R China;[5]Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 200032, Peoples R China;[6]Fudan Univ, Key Lab Hlth Technol Assessment, Minist Hlth, Shanghai 200032, Peoples R China;[7]Shanghai Univ Tradit Chinese Med, Shanghai 201203, Peoples R China;[8]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730099, Peoples R China;[9]Ganzhou Nankang Dist Tradit Chinese Med Hosp, Ganzhou 341499, Peoples R China;[10]Guangzhou Med Univ, Affiliated Hosp 2, Guangzhou 510260, Peoples R China;[11]Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Peoples R China;[12]Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 101121, Peoples R China;[13]China Acad Chinese Med Sci, Wangjing Hosp, Beijing 100102, Peoples R China;[14]Changchun Univ Tradit Chinese Med, Hosp Affiliated, Changchun 130021, Peoples R China

第一机构：Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China

通信机构：[1]corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China;[2]corresponding author), Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai 200032, Peoples R China;[3]corresponding author), Fudan Univ, Key Lab Hlth Technol Assessment, Minist Hlth, Shanghai 200032, Peoples R China.

年份：2024

卷号：263

外文期刊名：ENVIRONMENTAL RESEARCH

收录：;EI(收录号：20244117161335);Scopus(收录号：2-s2.0-85205578292);WOS:【SCI-EXPANDED(收录号:WOS:001332746900001)】；

基金：This work was partially supported by Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202202) , the National Key R&D & D Program China (2018YFC1704300) , the National Natural Science Foundation China (81730107, 82274548, 81973876, and 81929004) , the Program for Innovative Research Team of Ministry of Education of China (IRT1270) , and the Program for Innovative Research Team of Ministry of Science and Technology of China (2015RA4002) .

语种：英文

外文关键词：Air pollution; Particulate matter; Ozone; 25-Hydroxyvitamin D; Parathyroid hormone

摘要：Background: Maintaining normal levels of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) is crucial for preserving skeletal health. However, evidence regarding the associations of exposure to air pollution with serum 25(OH)D and PTH were limited and ambiguous. Hence, the objective of this cross-sectional study was to systematically evaluate the association between air pollution [particulate matter <= 2.5 mu m (PM2.5) and ozone (O3)] exposure and serum 25(OH)D and PTH levels in males aged 50 and above and postmenopausal female. Materials and methods: This study is multicenter, cross-sectional study within the framework of the ongoing China Community-based Cohort of Osteoporosis. The 1-year-average PM2.5 and O3 exposures prior to the baseline survey were estimated using random forest models with relatively high accuracy. Multiple linear regression models were employed to assess the associations between PM2.5 and O3 concentrations with the serum levels of 25(OH)D and PTH. Furthermore, mediation analysis was performed to scrutinize the potential mediating role of PTH in the interplay between PM2.5, O3, and serum 25(OH)D. Results: A total of 13194 participants were included. Our analysis showed that every 10 mu g/m3 increase in the 1year average PM2.5, were associated with -0.32 units (95% CI: 0.48, -0.17) of change in the 25(OH)D and 0.15 units (95% CI: 0.11, 0.19) of change in the PTH, respectively. Every 10 mu g/m3 increase in the 1-year average O3, were associated with -0.78 units (95% CI: 1.05, -0.51) of change in the 25(OH)D and 0.50 units (95% CI: 0.43, 0.57) of change in the PTH, respectively. Estimates of the mediation ratio indicated that increased PTH mediated a 50.48% negative correlation between PM2.5 exposure and circulating 25(OH)D level. Increased PTH mediated 69.61% of the negative effects of O3 exposure on circulating 25(OH)D level. Conclusions: Exposure to PM2.5 and O3 significantly diminished 25(OH)D while elevating PTH levels. Notably, the elevated PTH concentration partially mediates the associations between PM2.5 and O3 exposure and 25(OH)D level.