文献类型：期刊文献

英文题名：Association of HLA-DPB1 with Scleroderma and Its Clinical Features in Chinese Population

作者：Wang, Jiucun[1,2,3];Guo, Xinjian[4];Yi, Lin[4,5];Guo, Gang[6];Tu, Wenzhen[7];Wu, Wenyu[8];Yang, Li[9];Xiao, Rong[10];Li, Yuan[1,2];Chu, Haiyan[1,2];He, Dongyi[11];Jin, Li[1,2];Mayes, Maureen D.[4];Zou, Hejian[3,12];Zhou, Xiaodong[4]

第一作者：Wang, Jiucun

通信作者：Zhou, XD[1]

机构：[1]Fudan Univ, MOE, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China;[2]Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai 200433, Peoples R China;[3]Fudan Univ, Inst Rheumatol Immunol & Allergy, Shanghai 200433, Peoples R China;[4]Univ Texas Med Sch Houston, Div Rheumatol & Clin Immunogenet, Houston, TX 77030 USA;[5]Gansu Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[6]Yiling Hosp, Shijiazhuang, Hebei Province, Peoples R China;[7]Shanghai Tradit Chinese Med Integrated Hosp, Shanghai, Peoples R China;[8]Fudan Univ, Huashan Hosp, Div Dermatol, Shanghai 200433, Peoples R China;[9]Chengdu Univ TCM, Teaching Hosp, Div Rheumatol, Chengdu, Sichuan Provinc, Peoples R China;[10]Cent S Univ, Xiangya Hosp 2, Dept Dermatol, Changsha, Hunan, Peoples R China;[11]Shanghai Guanghua Hosp, Dept Rheumatol, Shanghai, Peoples R China;[12]Fudan Univ, Huashan Hosp, Div Rheumatol, Shanghai 200433, Peoples R China

第一机构：Fudan Univ, MOE, Key Lab Contemporary Anthropol, Shanghai 200433, Peoples R China

通信机构：[1]corresponding author), Univ Texas Med Sch Houston, Div Rheumatol & Clin Immunogenet, Houston, TX 77030 USA.

年份：2014

卷号：9

期号：1

外文期刊名：PLOS ONE

收录：;Scopus(收录号：2-s2.0-84900318817);WOS:【SCI-EXPANDED(收录号:WOS:000330621900099)】；

基金：The studies were supported by research grants from the US NIH NIAID UO1, 1U01AI09090 and the Science and Technology Committee of Shanghai Municipality (11410701800), International S&T Cooperation Program of China (2013DFA30870), the National Basic Research Program (2012CB944600), Ministry of Science and Technology (2011BAI09B00), Ministry of Health (201002007). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

语种：英文

摘要：Human leukocyte antigen DPB1 was reported to contain singly nucleotide polymorphisms conferring the strongest susceptibility to systemic sclerosis in Korean population. However, associations of specific DPB1 alleles with SSc vary in different ethnic populations. The aim of this study was to profile DPB1 alleles in Chinese population and to identify specific DPB1 alleles in association with SSc and clinical and serological features of SSc in Han Chinese. A cohort containing 338 patients with SSc and 480 gender-matched and unrelated controls were examined in the study. The HLA-DPB1 genotyping was performed with sequence-based typing method. Exact p-values were obtained (Fisher's test) from 2x2 tables of allele counts or allele carriers and disease status. Thirty eight DPB1 alleles were found in the cohort. DPB1*05:01 was the most common allele in this cohort. DPB1*03:01 and *13:01 were significantly increased in SSc. DPB1*13:01 association had already been described in other ethnic populations, whereas DPB1*03:01 was specific to Han Chinese patients with SSc. In addition, comparisons between SSc subsets indicated that patients carrying DPB1*03:01 were more likely to develop pulmonary fibrosis, DPB1*04 carriers were increased in SSc patients with anti-centromere autoantibodies and in contrast, SSc patients with homozygous DPB1*05:01 showed an opposite association with marginal significance.