文献类型：期刊文献

英文题名：Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling

作者：Yang, Fujia[1];Xiu, Minghui[2];Yang, Shipei[1];Li, Xu[2];Tuo, Wenjuan[1];Su, Yun[1,3];He, Jianzheng[1,3];Liu, Yongqi[1,4]

第一作者：Yang, Fujia

通信作者：He, JZ[1];Liu, YQ[1];He, JZ[2];Liu, YQ[3]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Key Lab Transfer Dunhuang Med & Prov & Minist Lev, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Coll Basic Med, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Tradit Chinese Med, Key Lab Transfer Dunhuang Med & Prov & Minist Lev, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;

年份：2021

卷号：2021

外文期刊名：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

收录：;Scopus(收录号：2-s2.0-85102382915);WOS:【SCI-EXPANDED(收录号:WOS:000627359000002)】；

基金：The authors appreciate the financial support received from the National Natural Science Foundation of China (Nos. 81973595 and 81960793), Gansu High Education Innovation Ability Improvement Project (No. 2019A-076), and the project of Provincial-level Key Laboratory for Molecular Medicine of Major Diseases and The Prevention and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University (No. FZYX17-18-6).

语种：英文

摘要：Historical literature and pharmacological studies demonstrate that Astragalus polysaccharide (APS) has anti-inflammatory and antioxidative effects. Studies into the longevity effects of APS are limited, and the molecular mechanism of lifespan extension by APS is not elucidated yet. Here, the longevity effect of APS was investigated in Drosophila melanogaster by feeding dose-dependent APS. APS significantly extended the lifespan and improved the reproduction. Meanwhile, APS increased locomotion, TAG level, and starvation resistance and reduced the mortality rate induced by hydrogen peroxide. The activities of superoxide dismutase (SOD) and catalase (CAT) were increased in flies treated with APS diet. Moreover, APS significantly enhanced expressions of antioxidant genes (Sod1, Sod2, and Cat), dFoxO, and 4E - BP, decreased the expressions of insulin-like peptides (dilp2, dilp3, and dilp5), and longevity gene MTH. Together, these results indicate that APS can prolong the lifespan by regulating antioxidant ability and insulin/IGF-1 signaling and also enhance the reproduction ability in Drosophila. APS may be explored as a novel agent for slowing the aging process and improving reproduction.