文献类型：期刊文献

英文题名：Aquaporins: Important players in the cardiovascular pathophysiology

作者：Zhang, Shangzu[1];Xie, Dingxiong[4];Ma, ChengJun[1];Yan, Chen[1];Li, Yangyang[1];Liu, Zhiwei[1];Ting, Zhou[1];Miao, Zhiming[1];Zhang, Yiming[1];Zhang, Liying[1,4];Liu, Yongqi[1,2,3]

第一作者：张尚智;张绍重;张尚珍

通信作者：Zhang, LY[1];Liu, YQ[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent & T, Lanzhou, Peoples R China;[3]Key Lab Dunhuang Med & Transformat Prov & Minister, Lanzhou, Peoples R China;[4]Gansu Inst Cardiovasc Dis, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：183

外文期刊名：PHARMACOLOGICAL RESEARCH

收录：;Scopus(收录号：2-s2.0-85135073829);WOS:【SCI-EXPANDED(收录号:WOS:000842911100004)】；

语种：英文

外文关键词：Aquaporin; Cardiovascular system; Localization; Pathophysiology; Modulators

摘要：Aquaporin is a membrane channel protein widely expressed in body tissues, which can control the input and output of water in cells. AQPs are differentially expressed in different cardiovascular tissues and participate in water transmembrane transport, cell migration, metabolism, inflammatory response, etc. The aberrant expression of AQPs highly correlates with the onset of ischemic heart disease, myocardial ischemia-reperfusion injury, heart failure, etc. Despite much attention to the regulatory role of AQPs in the cardiovascular system, the translation of AQPs into clinical application still faces many challenges, including clarification of the localization of AQPs in the cardiovascular system and mechanisms mediating cardiovascular pathophysiology, as well as the development of cardiovascular-specific AQPs modulators.Therefore, in this study, we comprehensively reviewed the critical roles of AQP family proteins in maintaining cardiovascular homeostasis and described the underlying mechanisms by which AQPs mediated the outcomes of cardiovascular diseases. Meanwhile, AQPs serve as important therapeutic targets, which provide a wide range of opportunities to investigate the mechanisms of cardiovascular diseases and the treatment of those diseases.