文献类型：期刊文献

中文题名：中医药调控肠道微生物群在溃疡性结肠炎治疗中的研究进展

英文题名：Research Progress on the Regulation of Gut Microbiota by Traditional Chinese Medicine in the Treatment of Ulcerative Colitis

作者：马春霞[1];李莹[1];田旭东[2];李彦龙[2];马艳花[1];马慧[1];陈振东[1]

第一作者：马春霞

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]甘肃省中医院脾胃病诊疗中心,甘肃兰州730050

第一机构：甘肃中医药大学中西医结合学院

年份：2026

卷号：40

期号：1

起止页码：95

中文期刊名：现代中药研究与实践

外文期刊名：Research and Practice on Chinese Medicines

基金：甘肃省名中医传承工作室项目(国中医药规财函﹝2021﹞242号);甘肃省自然科学基金项目(21JR11RA205)。

语种：中文

中文关键词：中医药;溃疡性结肠炎;肠道菌群;菌群代谢产物

外文关键词：Traditional Chinese medicine;ulcerative colitis;intestinal microbiota;metabolites of microbiota

摘要：溃疡性结肠炎(Ulcerative colitis,UC)作为常见慢性难治性疾病之一,其发病机制及治疗受到医学界广泛关注。近年来,随着对肠道微生物群作用的深入研究,发现UC患者存在明显的肠道菌群失调,其可通过破坏肠黏膜屏障、激发和加重炎症反应以及影响维持肠道平衡的重要代谢物—短链脂肪酸(Short-chain fatty acids,SCFAs)、胆汁酸(Bile acdis,BAs)、色氨酸(Tryptophan,TrP)而发挥致病作用。研究证实其可通过调节肠道菌群而在UC治疗中发挥重要作用。现将近年来通过调节肠道菌群发挥治疗UC作用的中药作一总结,旨在为中医药通过调节肠道菌群治疗UC提供科学依据,以期拓宽治疗途径,并为UC新型药物的研发提供新的思路。
Ulcerative colitis(UC)is a common chronic and refractory disease that has garnered significant attention from the medical community regarding its pathogenesis and treatment.In recent years,with in-depth research on the role of intestinal microbiota,it has been found that UC patients exhibit a marked imbalance in their intestinal flora.This imbalance can impair the intestinal mucosal barrier,trigger and exacerbate inflammatory responses,and affect key metabolites that maintain intestinal homeostasis-such as short-chain fatty acids(SCFAs),bile acids(BAs),and tryptophan(Trp)-thereby contributing to disease progression.As a therapeutic approach,traditional Chinese medicine(TCM)possesses diverse pharmacological effects and acts through multiple targets and pathways.The study reviews TCM interventions that have demonstrated efficacy in treating UC through intestinal flora regulation over the past three years,aiming to provide a scientific basis for TCM-based UC therapies,expand treatment options,and offer new insights into the development of novel UC medications.