文献类型：期刊文献

英文题名：ChangPu YuJin Tang improves Tourette disorder symptoms by modulating amino acid neurotransmitters in IDPN model rats

作者：Lu, Man-Qi[1,2];Shi, Zheng-Gang[1];Shang, Jing[1];Gao, Lu[3];Gao, Lei[1];Gao, Wei-Jiao[1]

第一作者：Lu, Man-Qi

通信作者：Shi, ZG[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200000, Peoples R China;[3]Shanxi Univ Chinese Med, Clin Med Coll 3, Pediat Teaching & Res Dept, Taiyuan 140100, Shanxi, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

外文期刊名：METABOLIC BRAIN DISEASE

收录：;Scopus(收录号：2-s2.0-85204598241);WOS:【SCI-EXPANDED(收录号:WOS:001318166600001)】；

基金：Acknowledgments The authors thank Han-Yuan Gao and Peng Feng for their early studies in the field of Tourette disorder. The authors are grateful to the editors and reviewers for their suggestions, which have greatly improved this paper.

语种：英文

外文关键词：Tourette disorder (TD); Changpu Yujin Tang; Glutamate; Gamma-aminobutyric acid

摘要：IntroductionChangpu Yujin Tang(CPYJT), a Chinese herbal compound, is an effective therapeutic strategy for pediatric patients with Tourette disorder (TD). Therefore, this work aims to investigate the therapeutic mechanisms of CPYJT.MethodsBehavioral and cellular ultrastructural evaluation of the therapeutic effects of CPYJT in TD model rats. Colorimetric methods, reverse transcription-quantitative PCR, and Western Blot were used to measure the altered levels of GLU, GABA, and the levels of VGLUT1, GLUD1, GABRA3, and GAD65 in the cortex, striatum, and thalamus of the TD model rats after 7, 14, 21, and 28 days of CPYJT administration.ResultsCPYJT significantly reduced stereotypic behavior and motor behavior scores in TD model rats. CPYJT ameliorates myelin structural damage in TD model rat neuronal cells. CPYJT decreased GLU content, elevated GABA content, decreased GLUD1 and VGLUT1 levels, and elevated GAD65 and GABRA3 levels in TD model rats' cortex, striatum, and thalamus. CPYJT has different regulatory time points in the cortex, striatum, and thalamus for critical factors of amino acid-based neurotransmission.ConclusionCPYJT protects behavioral and structural damage of neuronal cells in multiple brain regions in TD model rats.