文献类型：期刊文献

英文题名：Holistic concept guided quality control of traditional Chinese medicines for optimizing bioavailability

作者：Tian, Yawen[1,2,3];Yao, Juan[1,2,3];Gao, Qian[1,2,3];Zou, Linwei[1,2,3];Lu, Pengxiang[1,2,3];Guan, Tiantian[1,2,3];Liu, Xuefeng[1,2,3];Zhou, Shuangyan[4];Jin, Xiaojie[1,2,3]

第一作者：Tian, Yawen

通信作者：Jin, XJ[1];Jin, XJ[2];Jin, XJ[3];Zhou, SY[4]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Key Lab Dunhuang Med, Minist Educ, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Gansu Phamaceut Ind Innovat Res Inst, Lanzhou 730000, Peoples R China;[4]Chongqing Univ Posts & Telecommun, Chongqing Key Lab Big Data Bio Intelligence, Chongqing, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Key Lab Dunhuang Med, Minist Educ, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Gansu Phamaceut Ind Innovat Res Inst, Lanzhou 730000, Peoples R China;[4]corresponding author), Chongqing Univ Posts & Telecommun, Chongqing Key Lab Big Data Bio Intelligence, Chongqing, Peoples R China.|[10735]甘肃中医药大学;[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;

年份：2025

卷号：20

期号：1

外文期刊名：CHINESE MEDICINE

收录：;Scopus(收录号：2-s2.0-105022786597);WOS:【SCI-EXPANDED(收录号:WOS:001621523700001)】；

基金：This research was funded by Gansu Province Science Fund for Distinguished Young Scholars (No. 25JRRA246), and National Natural Science Foundation of China (No. 82004202), Provincial University industry support project in Gansu (2024CYZC-39).

语种：英文

外文关键词：Quality control; Bioavailability; Traditional Chinese medicines; Safety; Efficacy; Holistic concept

摘要：Traditional Chinese medicines (TCM) exerts multiple pharmacological effects, including anti-inflammation, antioxidation, and immune regulation, etc. However, its clinical efficacy and safety depend not only on the synergy of active substances but also on the precise control of potential toxic constituents. Therefore, a clear understanding of the in vivo behavior of TCM is essential. Bioavailability, as a key indicator for evaluating the clinical efficacy and safety of TCM, are increasingly recognized as interdependent. The ultimate goal of quality control is reflected in the bioavailability observed in clinical practice, making it a critical link for ensuring consistency and safety of TCM. This review summarizes recent progress on the mechanisms and roles of bioavailability in TCM quality control, and highlights that overcoming current bottlenecks requires cross-disciplinary integration. Guided by TCM theory and a holistic perspective, quality control should focus on biological effects rather than fragmented component analysis, and shift toward systematic and integrative approaches. Adhering to these principles is fundamental for improving bioavailability, enhancing clinical potential, and ensuring the safe use of TCM.