文献类型：期刊文献

中文题名：五味消瘿汤治疗良性甲状腺结节(痰热郁结型)临床研究

英文题名：A clinical study on treating benign thyroid nodules of the Tanre Yujie type with the Wuwei Xiaoying decoction

作者：秦双红[1];余臣祖[2];康学东[2];杨维杰[2];李芳芳[1]

第一作者：秦双红

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2019

卷号：11

期号：20

起止页码：73

中文期刊名：中医临床研究

外文期刊名：Clinical Journal Of Chinese Medicine

基金：甘肃中医药大学研究生创新基金,项目编号:CX2018-11;甘肃中医药大学附属医院科研项目,项目编号:gzfy-2017-02

语种：中文

中文关键词：五味消瘿汤;痰热郁结型;甲状腺结节;临床研究

外文关键词：The Wuwei Xiaoying decoction;The Tanre Yujie type(痰热郁结型);Thyroid nodules;Clinical research

摘要：目的:观察五味消瘿汤治疗良性甲状腺结节患者的临床疗效。方法:甲状腺结节患者60例,随机分为对照组30例和治疗组30例,对照组仅单纯随诊,治疗组则在对照组的基础上加用五味消瘿汤治疗,疗程为8周,治疗结束后,观察两组患者结节大小、证候积分、结节恶变高危因素积分的变化情况。结果:(1)有效率比较:结节缩小有效率:治疗组(36.67%)明显优于对照组(3.33%),差异有统计学意义(P<0.05);证候疗效有效率:治疗组(93.33%)明显优于对照组(6.67%),差异有统计学意义(P<0.05);(2)结节大小比较:治疗组前后对比差异有统计学意义(P<0.05);对照组前后对比差异无统计学意义(P>0.05);组间对比差异无统计学意义(P>0.05);(3)结节恶变高危因素积分比较:治疗组前后对比差异有统计学意义(P<0.05);对照组前后比较差异无统计学意义(P>0.05);组间对比差异有统计学意义(P<0.05);(4)证候积分比较:治疗组前后对比结果有显著性差异(P<0.05);对照组前后对比差异无统计学意义(P>0.05);组间对比差异有统计学意义(P<0.05)。结论:五味消瘿汤治疗良性甲状腺结节(痰热郁结型)患者的临床疗效显著,可以缩小甲状腺结节大小,改善患者的中医症状体征,降低结节的恶变高危因素积分,抑制结节恶变的进程,对甲状腺功能及自身免疫性抗体无影响,肝肾功等正常,安全可靠,疗效显著,值得临床推广应用。
Objective:To observe the clinical efficacy of the Wuwei Xiaoying decoction(五味消瘿汤)on benign thyroid nodules.Methods:60 patients were randomly divided into the control group and treatment group,30 cases in each.The control group was only followed up.The treatment group was treated with the Wuwei Xiaoying decoction more for 8 weeks.Results:Efficacy in nodules was 36.67%in the treatment group,was significantly better than 3.33%in the control group(P<0.05).The syndrome efficacy was 93.33%in treatment group,was significantly better than 6.67%in the control group(P<0.05).Nodule size showed a statistically significant difference between two groups(P<0.05).(3)The difference of high risk factors of nodular malignant transformation between the treatment group and the control group was statistically significant(P<0.05).(4)There were significant differences in syndrome scores between the treatment groups before and after treatment(P<0.05).There was no significant difference between the control group and the control group(P>0.05).There was a significant difference between the two groups(P<0.05).Conclusion:The Wuwei Xiaoying decoction is effective on benign thyroid nodules(stagnation of stagnation and stagnation).It can reduce the size of thyroid nodules,improve the symptoms of TCM symptoms,reduce the scores of malignant high-risk factors of nodules,and inhibit the malignant transformation of nodules.