文献类型：期刊文献

英文题名：Coxiella burnetii infection in the lumbar vertebra: a rare case report and review of literature

作者：Tan, Xingguo[1,2];Li, Feng[1,3];Zhang, Tao[1];Song, Mingjia[1];Zhang, Lian[1];Xing, Yuan[4];Wang, Yizhe[1,2];Chen, Long[1,2];Huang, Dashuai[1];Lu, Yanpeng[1,2];Li, Songkai[1]

第一作者：Tan, Xingguo

通信作者：Li, SK[1]

机构：[1]Chinese Peoples Liberat Army, Dept Spinal Surg, Hosp 940, Joint Logist Support Force, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China;[3]Chinese Peoples Liberat Army, Dept Orthoped, Hosp 943, Joint Logist Support Force, Wuwei, Peoples R China;[4]Chinese Peoples Liberat Army, Joint Logist Support Force, Dept Clin Lab, Hosp 940, Lanzhou, Peoples R China

第一机构：Chinese Peoples Liberat Army, Dept Spinal Surg, Hosp 940, Joint Logist Support Force, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Chinese Peoples Liberat Army, Dept Spinal Surg, Hosp 940, Joint Logist Support Force, Lanzhou, Peoples R China.

年份：2025

卷号：12

外文期刊名：FRONTIERS IN MEDICINE

收录：;Scopus(收录号：2-s2.0-105013242577);WOS:【SCI-EXPANDED(收录号:WOS:001550150600001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This work was funded by the Gansu Provincial Science and Technology Plan Key Project (21YF1FA179) and the General Clinical Research Project of 940th Hospital of Joint Logistics Support Force of PLA (2023YXKY021).

语种：英文

外文关键词：Coxiella burnetii; Q fever; infection; lumbar; case report; review

摘要：Coxiella burnetii is a bacterial pathogen of Q fever. Coxiella burnetii infection in the lumbar vertebra is a rare form of chronic Q fever, which poses significant obstacles in both diagnostic processes and therapeutic interventions. A 57-year-old male patient with a previous diagnosis of lumbar infection with unknown pathogen at another institution was admitted for treatment. At our institution, the patient underwent surgical interventions, including decompression through total laminectomy, lesion excision, intervertebral bone graft fusion, and fixation. Intraoperative pathological samples were analyzed using a specific multiplex quantitative polymerase chain reaction (qPCR) pathogenic microorganism detection, confirming the presence of Coxiella burnetii. Postoperatively, the patient received long-term antibiotic therapy by oral doxycycline and ciprofloxacin for a duration plan of 18 months. At the 6-month post-operative evaluation, the patient exhibited complete resolution of clinical symptoms, and imaging results revealed no evidence of infection recurrence, suggesting a clinical cure. The combination of decompression through total laminectomy, lesion excision, intervertebral bone graft fusion, and fixation alongside oral doxycycline and ciprofloxacin treatment has been demonstrated to be an effective therapeutic strategy for managing Coxiella burnetii infection in the lumbar vertebra.