文献类型：期刊文献

英文题名：A meta-analysis of the efficacy and safety of hot and cold contrast ablation for the treatment of lung cancer

作者：Yang, Kai[1];Meng, Hanyu[3];Guo, Chao[1];Que, Changhao[1];Wang, Jin[1];Gou, Yunjiu[2]

第一作者：杨魁;杨昆

通信作者：Gou, YJ[1]

机构：[1]Gansu Univ Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Lanzhou 730000, Peoples R China;[3]Shandong Second Med Univ, Weifang 261000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Lanzhou 730000, Peoples R China.

年份：2025

卷号：121

外文期刊名：CRYOBIOLOGY

收录：;Scopus(收录号：2-s2.0-105018344431);WOS:【SCI-EXPANDED(收录号:WOS:001598175400001)】；

基金：This research is funded by the following project.1. The "Innovative Star" Project for Postgraduate Students of Gansu Provincial Department of Education (Project No. 2025CXZX-947)2. Key Research and Development Project of Gansu Provincial Department of Science and Technology (Project No. 22YF7FA095)3. The internal project of Gansu Provincial People's Hospital (Project No. 2024KYQDJ-A-3)4. The internal project of Gansu Provincial People's Hospital (Project No. 22GSSYC-9)

语种：英文

外文关键词：Lung cancer; Radiofrequency ablation; Microwave ablation; Cryoablation; Meta-analysis

摘要：This meta-analysis evaluated and compared the efficacy and safety of cryoablation and thermal ablation in the treatment of lung cancer. A comprehensive search of relevant literature was conducted in databases including PubMed, Web of Science, Embase, The Cochrane Library, CNKI, Wanfang, and VIP, covering the period from the establishment of each database up to April 1, 2025. Studies were selected based on predefined inclusion and exclusion criteria. The meta-analysis was performed using Review Manager 5.3 software. Ultimately, 12 retrospective studies involving a total of 907 patients were included, with 422 patients undergoing cryoablation and 485 receiving thermal ablation. The results indicated that cryoablation was associated with a longer operative duration (p < 0.00001), but demonstrated superior intraoperative pain control (p < 0.00001) and a lower postoperative fever rate (p = 0.01). With regard to short-term and long-term therapeutic outcomes, as well as certain complications, no statistically significant differences were observed between the two modalities. In summary, both ablation techniques exhibited comparable efficacy in the treatment of lung cancer, with cryoablation offering improved intraoperative comfort and a reduced incidence of postoperative fever compared to thermal ablation.