文献类型：期刊文献

英文题名：Comprehensive analysis of aberrantly expressed profiles of messenger RNA in alcoholic liver disease

作者：Sun, Jinhui[1];Li, Baolong[2];Sun, Antao[3];Zhao, Kunpeng[4];Ma, Yanchun[5];Zhao, Jiuli[6];Pan, Hui[1];Song, Qingrui[1];Wang, Yan[1];Yu, Chunyu[1];Wang, Cui[1];Zhang, Huan[1];Zhang, Wenwen[1];Kong, Chenfan[1]

第一作者：Sun, Jinhui

通信作者：Sun, JH[1]

机构：[1]Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Gastroenterol, Hai Yun Cang 5th, Beijing 100700, Peoples R China;[2]Heilongjiang Univ Chinese Med, Ctr Safety Evaluat Drugs, Harbin, Heilongjiang, Peoples R China;[3]China Acad Chinese Med Sci, Guanganmen Hosp, Dept Hematol, Beijing, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[5]Heilongjiang Univ Chinese Med, Dept Acad Theory & Res, Harbin, Heilongjiang, Peoples R China;[6]Beijing Univ Chinese Med, Dongzhimen Hosp, Key Lab Chinese Internal Med, Minist Educ, Beijing, Peoples R China

第一机构：Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Gastroenterol, Hai Yun Cang 5th, Beijing 100700, Peoples R China

通信机构：[1]corresponding author), Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Gastroenterol, Hai Yun Cang 5th, Beijing 100700, Peoples R China.

年份：2019

卷号：120

期号：3

起止页码：4248

外文期刊名：JOURNAL OF CELLULAR BIOCHEMISTRY

收录：;Scopus(收录号：2-s2.0-85054571772);WOS:【SCI-EXPANDED(收录号:WOS:000458459600156)】；

语种：英文

外文关键词：Alcoholic liver disease (ALD); differential expression genes (DEGs); Gene Expression Omnibus (GEO); network

摘要：Background Alcoholic liver disease (ALD) is one of the major cause of morbidity and mortality of clinical liver disease worldwide. Until today, although many general therapies are carried out and several molecular targets have been proposed to act as the potential therapeutic targets, more accurate molecular targets and more effective therapeutic methods remain needed. Material and Methods In the study, we analyze the differential expression genes (DEGs) between the patients with ALD and healthy controls. Gene Ontology enrichment and KEGG signaling pathway analysis are performed to identify the function of DEGs. Some significant molecules are proposed to act as the potential therapeutic targets for ALD. RNA data of 15 ALD tissues and 7 normal tissues for RNA expression analysis were obtained. DEGs in ALD samples compared with normal tissues identified through the limma R package and subjected to network analysis. Results As a result, we obtained a total of 274 DEGs that mainly involved in biological processes related to the angiogenesis, stress reaction, synthesis, and metabolism of organic acids. Network analysis obtained several genes with high network degree and fold change. Some significant molecules are proposed to act as the potential therapeutic targets for ALD. Conclusions Our research identified some new progression-related genes of alcohol liver diseases, which could be regarded as the new targets for the early diagnosis and therapeutic management in ALD.