文献类型：期刊文献

英文题名：Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders

作者：Zhong, Sheng[1];Cheng, Yuan[1];Li, Fadong[1];Li, Dingpeng[1,3];Chang, Xudong[1];Zhang, Bo[1,2];Qi, Peng[1];Li, Ning[1,2];Xie, Xingwen[1,2]

第一作者：Zhong, Sheng

通信作者：Xie, XW[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Prov Second Peoples Hosp, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：59

外文期刊名：JOURNAL OF ORTHOPAEDIC TRANSLATION

收录：;Scopus(收录号：2-s2.0-105041095023);WOS:【SCI-EXPANDED(收录号:WOS:001791455300001)】；

基金：This work was supported by the Key Project of Traditional Chinese Medicine Research in Gansu Province (grant number: GZKZ-2024-9) ; Key Research Project of Traditional Chinese Medicine in Gansu Province (grant number: GZKZ-2020-6) ; Major Science and Technology Special Project Plan of Gansu Province (grant number: 22ZD6FA021-4) ; Lanzhou Municipal Science and Technology Plan Project (grant number: 2024-2-26) ; Research Project of Higher Education Institutions in Gansu Province (grant number: 2026CYZC-053) .

语种：英文

外文关键词：Circadian rhythm; Future perspectives; Molecular mechanism; Musculoskeletal disorders; Pathophysiology; Treatment

摘要：Circadian rhythm (CR), regulated by the central biological clock in the hypothalamus and synchronized with local clocks in peripheral tissues, orchestrates the physiology of localized tissues in response to the periodic rhythmic variations of the environment. Environmental cues and behavioral factors, such as light exposure, feeding, and exercise, can synchronize or desynchronize these rhythms, and abnormalities can lead to disruption of the human CR. Certain modern behaviors, such as traveling across time zones, shift work, and irregular eating patterns, disrupt the body's natural CR, thereby potentially contributing to the development of musculoskeletal disorders through multiple pathways. In this review, we summarize the role of CR in the physiology of the musculoskeletal system-encompassing bone, cartilage, tendons, and muscles-alongside the mechanisms by which CR disruption contributes to various musculoskeletal disorders. Additionally, we discuss interventions for treating musculoskeletal disorders based on CR, including resetting biological clocks or optimizing medication administration times. The translational potential of this articleA comprehensive understanding of the role of CR in the physiology and pathology of the musculoskeletal system offers significant therapeutic and preventative opportunities for musculoskeletal disorders, holding considerable importance for advancing the prevention and treatment of such conditions.