文献类型：期刊文献

中文题名：黄芪、红芪超滤物对高血压大鼠抗氧化及血管形态学的影响

英文题名：Effects of antioxidation and vascular morphology of ultrafiltrating substances of Astragalus and Hedysarumin hypertensive rats

作者：王志旺[1];刘永琦[1,2,3];魏舒畅[1];颜春鲁[1];王瑞琼[1]

第一作者：王志旺

机构：[1]甘肃中医学院;[2]甘肃中医学院甘肃省重大疾病分子医学与中医药防治研究重点实验室;[3]甘肃中医学院敦煌医学与转化教育部重点实验室

第一机构：甘肃中医药大学

年份：2014

卷号：34

期号：19

起止页码：1650

中文期刊名：中国医院药学杂志

外文期刊名：Chinese Journal of Hospital Pharmacy

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD2013_2014】；

语种：中文

中文关键词：黄芪超滤物;红芪超滤物;高血压;抗氧化;血管重构

外文关键词：Astragalus ultrafiltrating substances ; Hedysarurn ultrafiltrating substances ; hypertensive rats; antioxidation vascular remodeling

摘要：目的:从抗氧化方向对比研究黄芪超滤物与红芪超滤物对高血压大鼠的降压作用。方法:复制盐性高血压大鼠模型,通过观测大鼠血压、血管形态学、抗氧化酶及氧化产物等指标,对比研究黄芪、红芪超滤物降压作用及作用机制。结果:1.32 g·kg-1黄芪超滤物与1.68 g·kg-1红芪超滤物能明显缓解盐性高血压大鼠胸主动脉血管壁异常增厚,抑制大鼠血压的异常上升与体重的异常下降,提高血清超氧化物歧化酶与谷胱甘肽过氧化物酶的活性,降低丙二醛的含量(P<0.05,0.01)。结论:黄芪超滤物与红芪超滤物具有一定的降血压作用且二者的作用无明显差异,提高抗氧化能力、缓解血管壁重构是其降压机制之一。
OBJECTIVE To study the antihypertensive effects o{ ultrafiltrating substances of Astragalus and Hedysarum in hypertensive rats and the mechanism of actions from antioxidant direction. METHODS The salt hypertension rats were repli- cated, the blood pressure, vascular morphology, antioxidant enzymes and oxidation products were observed to test the antihy- pertensive effect and its mechanism of action. RESULTS 1.32 g. kg- 1 Astragalus ultrafiltrating substances and 1.68 g. kg 1 Hedysarum ultrafiltrating substances inhibited obviously the abnormal thickening of the aortic vessel wall, ascension of blood pressure and the decrease in body weight. Both of them increased SOD and GSH-PX activity and decreased the level of MDA in the serum（P〈0. 05,0. 01）. CONCLUSION The ultrafiltrating substances of Astragalus and Hedysarum have a certain hypotensive effects and have no significant difference between the two ones. Exaltation of antioxidant capacity and relief of vascular remodeling are the mechanisms of their antihypertension.