文献类型：期刊文献

英文题名：Inhibitory Effect of Astragalus Polysaccharide on Premetastatic Niche of Lung Cancer through the S1PR1-STAT3 Signaling Pathway

作者：Shen, Ming[1,2,3,4];Wang, Yan-jun[5];Liu, Zhao-hua[1,2,3,4];Chen, Yan-wen[1];Liang, Qian-kun[1];Li, Yang[1,2,3,4];Ming, Hai-xia[1,2,3,4,6]

第一作者：Shen, Ming

通信作者：Ming, HX[1];Ming, HX[2];Ming, HX[3];Ming, HX[4];Ming, HX[5]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Basic Discipline Integrat Tradit Chinese & Western, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Gansu Univ Key Lab Mol Med & Chinese Med Prevent &, Lanzhou, Peoples R China;[4]Key Lab Chron Dis Prevent & Treatment Tradit Chine, Lanzhou, Peoples R China;[5]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[6]Res Ctr Tradit Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Basic Discipline Integrat Tradit Chinese & Western, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Gansu Univ Key Lab Mol Med & Chinese Med Prevent &, Lanzhou, Peoples R China;[4]corresponding author), Key Lab Chron Dis Prevent & Treatment Tradit Chine, Lanzhou, Peoples R China;[5]corresponding author), Res Ctr Tradit Chinese Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：2023

外文期刊名：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000921571000001)】；

基金：The study was funded by the Key Scientific Research Projects of "Double First-Class" in Gansu Province (GSSYLXM-05), Natural Science Foundation of Gansu Province (20JR5RA178 and 20JR10RA320), Open Project of Gansu Research Center of Traditional Chinese Medicine (zyzx-2020-zx2), Scientific Research and Innovation Fund Project of the Gansu University of Chinese Medicine (2020KCZD-4 and 2021KCZD-1),Scientific Research and Cultivation Project of Integrated Traditional Chinese and Western Medicine in Gansu University of Chinese Medicine (2020-2021-12), Science and Technology Project in Lanzhou (2020-ZD-55 and 2021-1-96), and Gansu University of Chinese Medicine Graduate Innovation Fund for 2022 in the Basic Discipline of Integrated Traditional and Western Medicine (8).

语种：英文

摘要：As a common malignant tumor, the morbidity and mortality of lung cancer have been rising in recent years. The concept of "premetastatic niche" may lead to a revolutionary change in antitumor metastasis therapeutic strategies. Traditional Chinese medicine with multitargets and lower poisonous agents may be a potentially effective means to intervene in the "premetastatic niche (PMN)" to prevent and treat tumor metastasis. Astragalus polysaccharide (APS) is a substance with strong immune activity in Astragalus membranaceus that has excellent biological activities such as immunomodulation, anti-inflammatory, and antitumor. In this study, we constructed a tumor lung metastasis animal model to explore the intervention mechanism of APS on the premetastatic niche. We found that APS inhibited the formation of the lung premetastatic niche and inhibited the recruitment of myeloid-derived suppressor cells (MDSCs) in the lung. Mechanistically, we showed that the proteins and gene expression of S1PR1, STAT3, and p-STAT3 in the S1PR1/STAT3 signaling pathway were suppressed by APS. In line with the above findings, our results confirmed that APS may inhibit the accumulation of MDSCs in the premetastatic niche through the intervention of the S1PR1-STAT3 signaling pathway to achieve the antitumor effect.