文献类型：期刊文献

中文题名：肛周脓肿患者脓液病菌谱及药敏试验分析

英文题名：Analysis of pathogen spectrum and drug sensitivity test in pus of patients with perianal abscess

作者：赵高斯[1];张小元[1];高钰莹[1];姚君诚[2]

第一作者：赵高斯

机构：[1]甘肃中医药大学附属医院肛肠科,甘肃兰州730020;[2]通渭县中医医院普外科,甘肃定西743300

第一机构：甘肃中医药大学第二附属医院

年份：2021

卷号：27

期号：32

起止页码：9

中文期刊名：当代医学

外文期刊名：Contemporary Medicine

基金：甘肃中医药大学附属医院院内项目(GZFY-2017-08)。

语种：中文

中文关键词：肛周脓肿;细菌培养;药敏试验;病菌谱

外文关键词：Perianal abscess;Bacterial culture;Drug sensitivity test;Pathogen spectrum

摘要：目的研究肛周脓肿患者脓液中病菌谱的分布特征和药物敏感情况,为临床合理使用抗菌药物提供依据。方法选取2018年1月至2020年5月本院收治的肛周脓肿住院患者316例,采集患者脓液标本进行细菌培养及药敏试验,对其结果进行归纳分析。结果316例患者脓液细菌培养检出率为99.05%,厌氧菌11株(占2.81%),革兰阳性菌69株(占17.65%),革兰阴性菌311株(占79.54%)。大肠埃希菌属是检出最多的致病菌,228株占58.31%,其次是克雷伯菌属71株(占18.16%),葡萄球菌属42株(占10.74%)居于第三。药敏试验显示,存在敏感率为100.00%的抗生素,多是临床不常或特殊使用的抗菌药物,其他抗菌药均有不同程度耐药性。革兰阴性菌对头孢他啶、头孢吡肟、头孢西丁等7种抗菌药敏感率均达85.00%以上,革兰阳性菌对替考拉宁、左氧氟沙星等7种抗菌药敏感率均达80.00%以上,均为敏感药物。结论革兰阴性细菌是肛周脓肿感染的主要病原体,其中大肠埃希菌占比最高。临床上常用药物耐药性较高,早期可选头孢西丁、头孢吡肟、头孢他啶治疗肛周脓肿,根据药敏结果及时调整敏感药物。
Objective To study the distribution characteristics of Bacteria Spectrum and drug sensitivity of perianal abscess patients'pus,and to provide evidence rational use of antibiotics in clinic.Methods A total of 316 inpatients with perianal abscesses admitted to our hospital from January 2018 to May 2020 were selected and collected for bacterial culture and drug sensitivity test,inductive analysis of its results.Results In 316 patients,the detection rate of bacteria culture in pus was 99.05%,11 strains of anaerobic bacteria(2.81%),69 strains of Gram-positive bacteria(17.65%),311 strains of Gram-negative bacteria(79.54%).228 strains of Escherichia coli(58.31%),71 strains of Klebsiella(18.16%)and 42 strains of Staphylococcus(10.74%)were the most common pathogens.The drug sensitivity test showed that there are antibiotics with a sensitivity of 100.00%,most of which were seldom or specially used in clinic,and the other antibiotics were resistant to different degrees.The sensitivity of Gramnegative bacteria to ceftazidime and cefoxitin was over 85.00%,and that of Gram-positive bacteria to Teicoplanin and levofloxacin was over 80.00%,all of them were sensitive drugs.Conclusion Gram negative bacteria are the main pathogens of perianal abscess infection,among which Escherichia coli accounts for the highest proportion.In the early stage,cefoxitin,cefepime and ceftazidime were selected to treat perianal abscess,and then sensitive drugs were adjusted according to the results of drug sensitivity.