文献类型：期刊文献

中文题名：三七白及类方剂辅助治疗消化性溃疡临床效果的meta分析

英文题名：Meta-analysis of clinical effect of the formulas with Radix Notoginseng and Rhizoma Bletillae in the treatment of peptic ulcer

作者：崔岩[1];王天明[1];潘海邦[1]

第一作者：崔岩

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2022

卷号：29

期号：23

起止页码：5

中文期刊名：中国当代医药

外文期刊名：China Modern Medicine

基金：国家自然科学基金资助项目(81860850)。

语种：中文

中文关键词：消化性溃疡;三七;白及;联合治疗;随机对照试验;meta分析

外文关键词：Peptic ulcer;Radix Notoginseng;Rhizoma Bletillae;Combination therapy;Randomized controlled experiment;Meta-analysis

摘要：目的系统评价三七白及类方剂辅助治疗消化性溃疡(PU)的临床效果。方法通过计算机检索中国知网、维普、万方、中国生物医学文献、PubMed、Embase、Web of Science数据库中三七白及类方剂治疗PU的所有随机对照试验,检索时间自建库起至2021年10月。根据纳入及排除标准筛选文献并提取数据,采用RevMan 5.4软件对数据进行质量评价及meta分析。结果共纳入9项研究,总体样本747例,包括试验组379例,对照组368例。meta分析结果显示,采用三七白及类方剂的试验组,其溃疡愈合总有效率高于采用单纯西药治疗的对照组[OR=4.33,95%CI(2.37,7.89),P<0.00001]。而试验组的幽门螺杆菌转阴率与对照组比较,差异无统计学意义[OR=2.09,95%CI(0.96,4.56),P=0.06]。试验组的不良反应发生率与对照组比较,差异无统计学意义[OR=3.75,95%CI(0.30,47.72),P=0.31]。试验组的体征消失时间[MD=-2.35,95%CI(-2.81,-1.89),P<0.00001]、住院时间[MD=-3.17,95%CI(-3.68,-2.66),P<0.00001]和溃疡痊愈时间[MD=-8.55,95%CI(-10.69,-6.42),P<0.00001]均短于对照组。结论三七白及类方剂联合西药治疗PU的效果优于单用西药治疗,尤其在治疗恢复阶段效果极佳。
Objective To evaluate the clinical effect of the formulas with Radix Notoginseng and Rhizoma Bletillae in the treatment of peptic ulcer(PU).Methods A computer search was conducted for all randomized controlled trials on the treatment of PU with the formulas with Radix Notoginseng and Rhizoma Bletillae in CNKI,VIP,Wanfang,Chinese Biomedical literature,PubMed,Embase and Web of Science databases from self-built database to October 2021.Literature was screened according to inclusion and exclusion criteria and data were extracted.RevMan 5.4 software was used for quality evaluation and meta-analysis of data.Results A total of 9 studies were included,with a total sample of 747 patients,including 379 in experimental group and 368 in control group.The results of meta-analysis showed that the total effective rate of ulcer healing in the experimental group treated with the formulas with Radix Notoginseng and Rhizoma Bletillae was higher than that in the control group treated with western medicine alone(OR=4.33,95%CI[2.37,7.89],P<0.00001).There was no statistically significant difference in Helicobacter pylori conversion rate between the experimental group and the control group(OR=2.09,95%CI[0.96,4.56],P=0.06).There was no significant difference in the incidence of adverse reactions between the experimental group and the control group(OR=3.75,95%CI[0.30,47.72],P=0.31).The time of signs disappearance(MD=-2.35,95%CI[-2.81,-1.89],P<0.00001),hospital stay(MD=-3.17,95%CI[-3.68,-2.66],P<0.00001)and time of ulcer recovery(MD=-8.55,95%CI[-10.69,-6.42],P<0.00001)in experimental group were shorter than those in control group.Conclusion The the formulas with Radix Notoginseng and Rhizoma Bletillae combined western medicine treatment of PU the curative effect is superior to western medicine therapy,especially in the recovery phase of the treatment is excellent.