文献类型：期刊文献

中文题名：制萎扶胃浓缩丸对慢性萎缩性胃炎模型大鼠SOD活性、MDA和NO含量的影响

英文题名：Effect of Zhiwei Fuwei Concentrated Pill on SOD activity,MDA and NO Content in Model Rat with Chronic Atrophic Gastritis

作者：舒劲[1];李喜香[1];任远[2];李生财[1];吴国泰[2];洪秋菊[2]

第一作者：舒劲

机构：[1]甘肃省中医院;[2]甘肃中医学院

第一机构：甘肃省中医院

年份：2011

卷号：17

期号：2

起止页码：160

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2008】；

基金：甘肃省卫生厅重点中医药科研项目(GZK-2009-19)

语种：中文

中文关键词：慢性萎缩性胃炎;超氧化物歧化酶;丙二醛;一氧化氮;制萎扶胃浓缩丸

外文关键词：chronic atrophic gastritis; SOD; MDA; NO; Zhiwei Fuwei concentrated pill

摘要：目的:观察制萎扶胃浓缩丸对慢性萎缩性胃炎(CAG)模型大鼠血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)和一氧化氮(NO)含量的影响,探讨其防治慢性萎缩性胃炎的作用机制。方法:采用综合因素(30%乙醇与2%水杨酸钠混合液与10 mmol·L-1去氧胆酸钠交替ig,0.05%氨水日常饮用,结合主动免疫法,并令其饥饱失常)诱发大鼠建立实验性慢性萎缩性胃炎模型,ig制萎扶胃浓缩丸(FW)高、中、低剂量(分别为1.67,0.84,0.42 g·kg-1)75 d后测定血清和胃黏膜SOD活性和MDA,NO含量。结果:制萎扶胃浓缩丸高、低剂量明显增高CAG模型大鼠血清SOD活性(P<0.01),高剂量明显增高CAG模型大鼠胃黏膜SOD活性;各剂量均能降低CAG模型大鼠血清和胃黏膜MDA含量(P<0.01,或P<0.05);高、中剂量能升高CAG模型大鼠胃黏膜NO含量(P<0.05),各剂量对血清NO含量有降低的趋势。结论:制萎扶胃浓缩丸能改变CAG模型大鼠胃黏膜组织和血液的SOD活性和MDA,NO含量,使其趋于正常水平,通过抗氧化、清除自由基作用有效防治慢性萎缩性胃炎。
Objective： To observe the effect of Zhiwei Fuwei concentrated pill（FW） for superoxide dismutase（SOD） activity,malondialdehyde（MDA） and nitric oxide（NO） content in model rats,of chronic atrophic gastritis（CAG）,and to investigate the mechanism of FW in prevention and treatment of CAG.Method： An experimental CAG model was established by comprehensive factors,including using alternative ingestion with 30% ethanol and 2% sodium salicylate mixed solution and 10 mmol·L-1 sodium deoxycholate,drinking of 0.05% ammonia daily,combining with active immunization,followed by either hunger or gorge in wistar rats.The SOD activity and MDA content in serum and gastric mucosa were determined after 75 days of FW treatment（1.67,0.84,0.42 g·kg-1）.Result：The high and low dosage of FW could promote SOD activity in serum significantly（P 0.01）.The high dosage could promote SOD activity in gastric mucosa.The FW could reduce MDA content,and increase NO content in gastric mucosa.Conclusion：FW can make SOD activity,MDA and NO content tend to be normal by antioxidating and scavenging free radicals to prevent and treat CAG effectively.