详细信息
中药促进脑缺血血管生成研究进展
Research Progress in TCM Promoting the Development of Cerebral Ischemia Angiogenesis
文献类型:期刊文献
中文题名:中药促进脑缺血血管生成研究进展
英文题名:Research Progress in TCM Promoting the Development of Cerebral Ischemia Angiogenesis
作者:黄生辉[1,2];李妍怡[3];巩婷[3]
第一作者:黄生辉
机构:[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]甘肃中医药大学附属医院神经内科,甘肃兰州730000;[3]甘肃省中医院脑病科,甘肃兰州730050
第一机构:甘肃中医药大学中西医结合学院
年份:2018
卷号:25
期号:7
起止页码:137
中文期刊名:中国中医药信息杂志
外文期刊名:Chinese Journal of Information on Traditional Chinese Medicine
收录:CSTPCD;;CSCD:【CSCD_E2017_2018】;
基金:国家自然科学基金(81460686)
语种:中文
中文关键词:中药;脑缺血;血管生成;血管内皮生长因子;Notch信号通路;Wnt信号通路;综述
外文关键词:TCM;cerebral ischemia;angiogenesis;VEGF;Notch signaling pathway;Wnt signaling pathway;review
摘要:单味药及其有效成分、中药复方及中成药对血管的促进、抑制作用为目前研究热点,但中药对脑缺血后促进血管生成的作用及机制相关研究尚未深入。本文对中药促进脑血管生成的中医理论、体外研究、在体研究进行综述,并对通过Notch和Wnt信号通路调控血管生成的机制研究进行重点阐述,为药理作用机制研究及新药研发提供参考。
The promotion or inhibition of blood vessels by TCM, active ingredients of TCM, TCM compounds, and Chinese patent drugs is currently a research hotspot, with relatively abundant research. However, the study of the role and profound mechanism of TCM on angiogenesis after cerebral ischemia is relatively rare. Therefore, this article reviewed theories, in vitro studies and in vivo studies on the promotion of cerebral angiogenesis by TCM, and summarized the studies on TCM regulation of angiogenesis through Notch and Wnt signaling pathway mechanisms, with a purpose to provide references for resarch on related mechanisms and development of new deugs.
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