文献类型：期刊文献

英文题名：Association of Copper with Atherosclerosis and Treatment Strategies

作者：Li, Jiawei[1];Yi, Lin[1,3];Zhang, Lingna[1];Shen, Lufan[1];Lu, Yuyuan[1];Wang, Hong[1];Chen, Xiaojie[1];Kou, Yushun[1];Wang, Yiyuan[1];Ma, Ruiling[1];Teng, Zhenjie[2]

第一作者：李佳蔚

通信作者：Yi, L[1];Teng, ZJ[2];Yi, L[3]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Dept Cardiovasc Med, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Chron Dis Lab, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Dept Cardiovasc Med, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Tradit Chinese Med, Chron Dis Lab, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;

年份：2025

外文期刊名：JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001587332400001)】；

基金：This work was supported by grants from the National Natural Science Foundation of China, No. 82160842; Traditional Chinese Medicine scientific research Project in Gansu Province in 2023, No. GZKP-2023-40; Open Subjects of Dunhuang Medicine in the Key Laboratory of Translation of the Ministry of Education, No. DHYX23-07; General Program of the Joint Scientific Research Fund, No. 23JRRA1521; 2025 "Innovation and Entrepreneurship Fund" project for graduate students of Gansu University of Traditional Chinese Medicine, NO. 2025CXCY-012.

语种：英文

外文关键词：Copper; Atherosclerosis; Copper metabolism; Cuproptosis; Copper homeostasis

摘要：Atherosclerosis (AS) is a chronic inflammatory disease characterized by the formation of fibrous fatty lesions or plaques within the arterial wall, which causes a large amount of morbidity and mortality worldwide. Copper is a mineral nutrient essential for the human body and is essential for maintaining the normal function of multiple human systems, including the cardiovascular system. Imbalance of copper homeostasis has been increasingly considered as a key factor affecting the pathogenesis and disease progression of AS. This article summarizes the complex association between copper ions and AS, focusing in particular on the key roles of copper metabolism, copper homeostasis and copper death. It aims to reveal the mechanism of action of copper ions in AS and explore treatment strategies targeting copper metabolism, copper death and copper homeostasis imbalance in relation to atherosclerosis, with a view to providing new perspectives and strategies for the treatment and prevention of AS.