文献类型：期刊文献

英文题名：Diphenylamine modified phthalocyanine for phototherapy of melanoma

作者：Wang, Hongwei[1];Guo, Yanan[1];Huang, Qin[1];Mu, Shuai[3];Yang, Yi[1];Wang, Huayu[1];Liu, Yali[1];Liu, Xiaoyan[1];Wang, Xin[2];Ma, Junbao[1];Zhang, Haixia[1]

第一作者：Wang, Hongwei

通信作者：Ma, JB[1];Zhang, HX[1];Wang, X[2]

机构：[1]Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Nat Prod Chem, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Urol, Lanzhou 730000, Peoples R China;[3]Lanzhou Univ, Gansu Clin Med Res Ctr Cardiovasc Dis, Hosp 1, Clin Med Coll 1, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Nat Prod Chem, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Nat Prod Chem, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Urol, Lanzhou 730000, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20264021571342);Scopus(收录号：2-s2.0-105051852501);WOS:【SCI-EXPANDED(收录号:WOS:001886483200001)】；

基金：This research was financially supported by the National Natural Science Foundation of China (No. 22574069) to H. Zhang, the Talent Scientific Fund of Lanzhou University (No. 561120234) to J. Ma, and the Lanzhou Science and Technology Program (No. 2025-5-133) to X. Wang. We are grateful to Dr. Binyang Jiang (Shanghai Institute of Organic Chemistry) for the guidance and assistance with the theoretical calculations in this work.

语种：英文

外文关键词：Body fluids - Gas generators - Laser beam effects - Mammals - Nanoparticles - Oncology - Red Shift

摘要：Phthalocyanines (Pc) have been widely employed as photosensitizers, but their rational design for application in the phototheranostics field remains challenging. Herein, a series of Pc derivatives with tunable electron-donating capabilities were designed to strengthen the intramolecular charge transfer (ICT) process. Upon the introduction of strong electron-donating substituents linked via nitrogen bridges, these complexes exhibited gradually red-shifted absorption maxima (up to 744 nm for PcMD), narrowed HOMO-LUMO gaps, quenched fluorescence emission, and promoted intersystem crossing (ISC). These favorable features consequently contributed to enhanced reactive oxygen species (ROS) generation and improved photothermal conversion efficiency. Further in vitro experiments were conducted using bovine serum albumin and folic acid co-modified PcMD (PcMD@BSA-FA). This nanoparticle exhibited strong photocytotoxicity to A375 melanoma cells upon 730 nm laser irradiation, and the corresponding half-maximal inhibitory concentration (IC50) was determined to be 3.2 & micro;M. In addition, this nanoparticle enabled concentration-dependent photoacoustic (PA) imaging, with prominent tumor accumulation reaching a maximum at 8 h post-injection. This work demonstrates that regulating the ICT process serves as an effective strategy to enhance the phototheranostic performance of Pc, and the PcMD@BSA-FA nanoparticles hold great potential for PA imaging-guided synergistic cancer phototherapy.