文献类型：期刊文献

英文题名：The role of IL-37 in gastrointestinal diseases

作者：Wang, Qiang[1];Zhang, Guangrun[2];An, Caiping[3];Hambly, Brett D.[4];Bao, Shisan[5,6]

第一作者：王强

通信作者：An, CP[1];Bao, SS[2];Bao, SS[3]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Dept Anat, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Dept Nephrol, Lanzhou, Peoples R China;[4]Torrens Univ Australia, Ctr Hlth Futures, Sydney, NSW, Australia;[5]Gansu Univ Chinese Med, Affiliated Hosp 3, Foreign Affairs Off, Baiyin, Peoples R China;[6]First Peoples Hosp Baiyin, Foreign Affairs Off, Baiyin, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Nephrol, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp 3, Foreign Affairs Off, Baiyin, Peoples R China;[3]corresponding author), First Peoples Hosp Baiyin, Foreign Affairs Off, Baiyin, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85202212370);WOS:【SCI-EXPANDED(收录号:WOS:001298637300001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The current study is partially supported by a grant from Gansu Provincial Science and Technology Project (Project No: 23JDKD0001).

语种：英文

外文关键词：IL-37; gastrointestinal; inflammation; cancer; colorectal cancer

摘要：Gastrointestinal mucosal surface is frequently under challenge due to it's the large surface area and most common entry of microbes. IL-37, an anti-inflammatory cytokine, regulates local and systemic host immunity. H. pylori infection leads to the inhibition of IL-37 in the gastric mucosa, contributing to heightened mucosal inflammation and destruction, thereby facilitating increased proliferation of H. pylori. Food allergy, due to immune dysregulation, also contribute to GI injury. On the other hand, elevated levels of IL-37 observed in gastric cancer patients align with reduced host immunity at the cellular and humoral levels, indicating that IL-37 may contribute to the development of gastric cancer via suppressing pro-inflammatory responses. While IL-37 provides protection in an IBD animal model, the detection of highly produced IL-37 in IBD patients suggests a stage-dependent role, being protective in acute inflammation but potentially exacerbates the development of IBD in chronic conditions. Moreover, elevated colonic IL-37 in CRC correlates with overall survival time and disease time, indicating a protective role for IL-37 in CRC. The differential regulation and expression of IL-37 between upper- and lower-GI organs may be attributed to variations in the microbial flora. This information suggests that IL-37 could be a potential therapeutic agent, depending on the stage and location.