文献类型：期刊文献

英文题名：The efficacy and safety of thrombolytic agents for patients with cerebral infarction A protocol for systematic review and network meta-analysis

作者：Huang, Shenghui[1,2];Jiang, Junshi[2];Xu, Zhiming[2];Lu, Cuncun[3];Cao, Fang[1];Sang, Wengxia[1];Gong, Ting[4];Li, Yanyi[4]

第一作者：黄生辉;Huang, Shenghui

通信作者：Li, YY[1]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp, Dept Neurol, Lanzhou, Gansu, Peoples R China;[2]Guansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China;[4]Gansu Prov Hosp Tradit Chinese Med, Dept Encephalopathy, 1 Dong Gang West Rd, Lanzhou, Peoples R China

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Encephalopathy, 1 Dong Gang West Rd, Lanzhou, Peoples R China.

年份：2018

卷号：97

期号：52

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85059225079);WOS:【SCI-EXPANDED(收录号:WOS:000456338700029)】；

基金：The pilot project of Chinese and Western Medicine Clinical Collaboration for Major Difficult Diseases and National Natural Science Foundation of China (81460686).

语种：英文

外文关键词：cerebral infarction; network meta-analysis; systematic review; thrombolytic agent

摘要：Background: Cerebral infarction is a commonly dangerous disease also with high morbidity and mortality. Thrombolytic agent is an effective method to treat it, but their relative efficacy and safety are unclear. A network meta-analysis (NMA) will be conducted to resolve this urgent problem. Methods: The PubMed, Embase, and Cochrane library will be systematically search from their inception to November 2018. All randomized controlled trials (RCTs) will be included this NMA and their risk of bias will be assessed using Cochrane handbook tool. The outcomes of efficacy and safety including: Modified Rankin Scale scores, reperfusion rate, incidence of symptomatic intracerebral hemorrhage and all-cause mortality. A network meta-analysis will be performed using Rx64 3.5.1 software and pairwise meta-analysis will be conducted using Stata 12.0 software (Stata Corp., College Station, Texas). Grading of Recommendations Assessment, Development and Evaluation (GRADE) will be used to assess quality of outcomes. Results: The results of NMA will be published in a peer-reviewed journal. Conclusion: The NMA will provide a comprehensive evidence summary on thrombolytic agents for patients with cerebral infarction.