文献类型：期刊文献

英文题名：Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study

作者：Jia, Jianping[1,2];Zhao, Tan[1,2];Liu, Zhaojun[1,2];Liang, Yumei[1,2];Li, Fangyu[1,2];Li, Yan[1,2];Liu, Wenying[1,2];Li, Fang[3];Shi, Shengliang[4];Zhou, Chunkui[5];Yang, Heyun[6];Liao, Zhengluan[7];Li, Yang[8];Zhao, Huiying[9];Zhang, Jintao[10];Zhang, Kunnan[11];Kan, Minchen[12];Yang, Shanshan[13];Li, Hao[14];Liu, Zhongling[15];Ma, Rong[16];Lv, Jihui[17];Wang, Yue[18];Yan, Xin[19];Liang, Furu[20];Yuan, Xiaoling[21];Zhang, Jinbiao[22];Gauthier, Serge[23,24];Cummings, Jeffrey[25,26]

第一作者：Jia, Jianping

通信作者：Jia, JP[1]

机构：[1]Capital Med Univ, Xuanwu Hosp, Natl Ctr Neurol Disorders, Innovat Ctr Neurol Disorders, Beijing, Peoples R China;[2]Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China;[3]Capital Med Univ, Fuxing Hosp, Dept Geriatr, Beijing, Peoples R China;[4]Guangxi Med Univ, Affiliated Hosp 2, Dept Neurol, Nanjing, Guangxi, Peoples R China;[5]Jilin Univ, Teaching Hosp 1, Dept Neurol, Jilin, Peoples R China;[6]First Hosp Kunming, Dept Neurol, Kunming, Yunnan, Peoples R China;[7]Zhejiang Prov Peoples Hosp, Dept Psychiat, Zhenjiang, Peoples R China;[8]Shanxi Med Univ, Hosp 1, Dept Neurol, Taiyuan, Shanxi, Peoples R China;[9]Shijiazhuang City Hosp, Dept Neurol, Shijiazhuang, Hebei, Peoples R China;[10]960th Hosp PLA, Dept Neurol, Jinan, Shandong, Peoples R China;[11]Jiangxi Prov Peoples Hosp, Dept Neurol, Nanchang, Jiangxi, Peoples R China;[12]Handan Cent Hosp, Dept Neurol, Handan, Hebei, Peoples R China;[13]Daqing Oilfield Gen Hosp, Dept Neurol, Daqing, Heilongjiang, Peoples R China;[14]First Peoples Hosp Yibin, Dept Neurol, Yibin, Sichuan, Peoples R China;[15]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Neurol, Lanzhou, Gansu, Peoples R China;[16]Dongguan Peoples Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China;[17]Beijing Geriatr Hosp, Dept Psychiat, Beijing, Peoples R China;[18]Capital Med Univ, Beijing Anding Hos, Dept Neurol, Beijing, Peoples R China;[19]Beijing Jishuitan Hosp, Dept Neurol, Beijing, Peoples R China;[20]Baotou Cent Hosp, Dept Neurol, Baotou, Inner Mongolia, Peoples R China;[21]Liaocheng Peoples Hosp, Dept Neurol, Liaocheng, Shandong, Peoples R China;[22]Shandong Univ, Cheeloo Coll Med, Weihai Municipal Hosp, Dept Neurol, Jinan, Shandong, Peoples R China;[23]McGill Univ, McGill Ctr Studies Aging, Dept Neurol & Neurosurg, Montreal, PQ, Canada;[24]McGill Univ, McGill Ctr Studies Aging, Dept Psychiat, Montreal, PQ, Canada;[25]Univ Nevada, Dept Brain Hlth, Chambers Grundy Cte Transformat Neurosci, Las Vegas, NV USA;[26]Cleveland Clin Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA

第一机构：Capital Med Univ, Xuanwu Hosp, Natl Ctr Neurol Disorders, Innovat Ctr Neurol Disorders, Beijing, Peoples R China

通信机构：[1]corresponding author), Capital Med Univ, Xuanwu Hosp, Natl Ctr Neurol Disorders, Innovat Ctr Neurol Disorders, Beijing, Peoples R China.

年份：2023

卷号：380

外文期刊名：BMJ-BRITISH MEDICAL JOURNAL

收录：;Scopus(收录号：2-s2.0-85146851597);WOS:【SCI-EXPANDED(收录号:WOS:001046393000010)】；

基金：This study was supported by the Key Project of the National Natural Science Foundation of China (81530036); the National Key Scientific Instrument and Equipment Development Project (31627803); the Key Project of the National Natural Science Foundation of China (U20A20354); Beijing Scholars Program; Beijing Brain Initiative from Beijing Municipal Science and Technology Commission (Z201100005520016, Z201100005520017, Z161100000216137); CHINACANADA Joint Initiative on Alzheimer's Disease and Related Disorders (81261120571); Mission Program of Beijing Municipal Administration of Hospitals (SML20150801); National Natural Science Foundation of China (30370494, 30410303095, 30470615); The National Science and Technology Foundation of China (2004BA714B06-1, 2003CB517102, 2006CB500700, 2006BAI02B01, 2011CB504101, 2011ZX09307001-03); Beijing Natural Science Foundation (7071004); Major project of Beijing Municipal Science and Technology Commission (D111107003111009); and Sailing Plan of Beijing Municipal Administration of Hospitals (ZY201301). The funders had no role in considering the study design or in the collection, analysis, interpretation of data, writing of the report, or decision to submit the article for publication.

语种：英文

摘要：OBJECTIVE To identify an optimal lifestyle profile to protect against memory loss in older individuals. DESIGN Population based, prospective cohort study. SETTING Participants from areas representative of the north, south, and west of China. PARTICIPANTS Individuals aged 60 years or older who had normal cognition and underwent apolipoprotein E (APOE) genotyping at baseline in 2009. MAIN OUTCOME MEASURES Participants were followed up until death, discontinuation, or 26 December 2019. Six healthy lifestyle factors were assessed: a healthy diet (adherence to the recommended intake of at least 7 of 12 eligible food items), regular physical exercise (>= 150 min of moderate intensity or >= 75 min of vigorous intensity, per week), active social contact (>= twice per week), active cognitive activity (>= twice per week), never or former smoking, and never drinking alcohol. Participants were categorised into the favourable group if they had four to six healthy lifestyle factors, into the average group for two to three factors, and into the unfavourable group for zero to one factor. Memory function was assessed using the World Health Organization/University of California-Los Angeles Auditory Verbal Learning Test, and global cognition was assessed via the Mini-Mental State Examination. Linear mixed models were used to explore the impact of lifestyle factors on memory in the study sample. RESULTS 29 072 participants were included (mean age of 72.23 years; 48.54% (n=14 113) were women; and 20.43% (n=5939) were APOE epsilon 4 carriers). Over the 10 year follow-up period (2009-19), participants in the favourable group had slower memory decline than those in the unfavourable group (by 0.028 points/year, 95% confidence interval 0.023 to 0.032, P<0.001). APOE epsilon 4 carriers with favourable (0.027, 95% confidence interval 0.023 to 0.031) and average (0.014, 0.010 to 0.019) lifestyles exhibited a slower memory decline than those with unfavourable lifestyles. Among people who were not carriers of APOE epsilon 4, similar results were observed among participants in the favourable (0.029 points/year, 95% confidence interval 0.019 to 0.039) and average (0.019, 0.011 to 0.027) groups compared with those in the unfavourable group. APOE epsilon 4 status and lifestyle profiles did not show a significant interaction effect on memory decline (P=0.52). CONCLUSION A healthy lifestyle is associated with slower memory decline, even in the presence of the APOE epsilon 4 allele. This study might offer important information to protect older adults against memory decline.