文献类型：期刊文献

英文题名：Association between a composite metabolic index and mortality in critically ill patients with pulmonary hypertension: a retrospective cohort study

作者：Xiang, Xiao-Jun[1,2,3];Ma, Dong-Yu[5];Liu, Meng-Yang[5];Ma, Li[1,4];Sun, Xiao-Long[5];Li, Jian-Feng[2];Zhang, Wen-Bo[1];Xie, Ping[1,2,5]

第一作者：Xiang, Xiao-Jun

通信作者：Xie, P[1];Xie, P[2];Xie, P[3]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Natl Clin Res Ctr Cardiovasc Dis, Dept Cardiovasc Med, Branch Construct Unit, Lanzhou 730000, Peoples R China;[3]Chongqing Three Gorges Med Coll, Dept Resp & Crit Care Med, Affiliated Fengjie Hosp, Chongqing 404600, Fengjie, Peoples R China;[4]Gansu Matern & Child Hlth Care Hosp, Gansu Cent Hosp, Dept Geriatr, Lanzhou 730000, Peoples R China;[5]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Natl Clin Res Ctr Cardiovasc Dis, Dept Cardiovasc Med, Branch Construct Unit, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：16

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：;Scopus(收录号：2-s2.0-105047007317);WOS:【SCI-EXPANDED(收录号:WOS:001848942300007)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant No. 82460051), the Major Project of Gansu Province Joint Research Fund (Grant No. 24JRRA886), the Natural Science Foundation of Gansu Province (Grant No. 26JRRA712), and the Maternal and Child Health Care Hospital of Gansu Province (Gansu Provincial Central Hospital) (Grant No. MCCH2025-3-16).

语种：英文

外文关键词：Pulmonary hypertension; Metabolic dysfunction; FBG/HDL-C; 90-day mortality; Retrospective cohort

摘要：Pulmonary hypertension (PH) is a heterogeneous condition with variable prognosis across World Health Organization (WHO) subtypes. The fasting blood glucose to high-density lipoprotein cholesterol (FBG/HDL-C) ratio has been suggested as a metabolic predictor of adverse outcomes in critically ill patients, but its prognostic value in PH remains unclear. This retrospective cohort included 281 ICU patients with pulmonary hypertension (PH) from MIMIC-IV (2008-2022). Patients were divided into tertiles based on ln(1 + FBG/HDL-C). The primary endpoint was 90-day all-cause mortality, which was assessed using Cox proportional hazards regression, with exploratory subgroup analyses by WHO PH groups. In fully adjusted models, patients in the highest tertile of ln(1 + FBG/HDL-C) had higher 90-day mortality than those in the lowest tertile (HR = 3.30, 95% CI: 1.82, 5.97; p < 0.001). Elevated risk was observed across WHO PH Groups 1, 2, and 5, with the most statistically robust and clinically interpretable association in Group 2 (HR = 2.66, 95% CI: 1.40, 5.05; p = 0.003). Elevated FBG/HDL-C ratio was independently associated with 90-day mortality, with the association in Group 2 being the most statistically stable and clinically interpretable.