文献类型：期刊文献

英文题名：Intestinal-Bone Axis Mediated by Bifidobacterium: Mechanistic Analysis and Therapeutic Potential in Osteoporosis

作者：Li, Fadong[1];Zhang, Haoze[1];Zhang, Boran[1];Xie, Xingwen[1,2];Li, Ning[1,2]

第一作者：Li, Fadong

通信作者：Xie, XW[1];Li, N[1];Xie, XW[2];Li, N[2]

机构：[1]Gansu Univ Tradit Chinese Med, Sch Clin Chinese Med, Lanzhou 730013, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou 730020, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Sch Clin Chinese Med, Lanzhou 730013, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp, Lanzhou 730020, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

卷号：14

期号：9

外文期刊名：MICROORGANISMS

收录：;Scopus(收录号：2-s2.0-105051836836);WOS:【SCI-EXPANDED(收录号:WOS:001891311100001)】；

基金：This work was supported by the In-house Talent Training Project of the Affiliated Hospital of Gansu University of Chinese Medicine (Financial No.: 070005583); the Preclinical Study of Innovative Traditional Chinese Medicine Yangbing Plaster Hydrogel for the Treatment of Knee Synovitis (No.: 2026CYZC-053), Gansu Province University Industry Support Project; the National Traditional Chinese Medicine Key Specialty Construction Project-Orthopedics and Traumatology (Rehabilitation Orthopedics Direction) (TCM Administration Letter of Gansu 2026(1)); and the Inheritance Studio of Chief TCM Doctor Li Ning, Gansu Province.

语种：英文

外文关键词：Bifidobacterium; osteoporosis; gut-bone axis; probiotics; gut microbiome; bone metabolism

摘要：Osteoporosis is one of the most prevalent metabolic bone diseases worldwide, and current pharmacological options are limited by adverse effects and are poorly suited to long-term use, underscoring the need for novel therapeutic targets. Bifidobacterium, one of the most representative beneficial bacterial genera in the human gut, has been linked to bone mineral density, and supplementation with specific strains improves bone metabolic parameters in animal models of osteoporosis. This narrative review examines the molecular mechanisms through which Bifidobacterium may protect bone via the gut-bone axis, encompassing four interconnected dimensions: reinforcement of the intestinal barrier, modulation of the immune network, remodeling of the gut microbiota, and production of bone-protective metabolites. The review makes three principal contributions. First, it establishes a four-tier mechanistic framework of Bifidobacterium-mediated regulation of osteoporosis in which the evidence is stratified into three categories-direct evidence from Bifidobacterium-specific studies, indirect evidence from other probiotics, and general mechanisms of gut microbiota-regulated bone metabolism-thereby strengthening the rigor of each argument and explicitly distinguishing evidence derived from Bifidobacterium-specific studies from that based on other probiotics or general gut-microbiota mechanisms throughout the review. Second, it systematically compares the osteoprotective efficacy of different Bifidobacterium strains (Bifidobacterium longum, Bifidobacterium lactis, Bifidobacterium adolescentis, etc.), highlighting the central importance of strain specificity. Third, it evaluates the strength of the evidence and identifies knowledge gaps for each mechanistic pathway. Most current evidence derives from cross-sectional studies and animal models; causal relationships await validation in large-scale prospective cohort studies and randomized controlled trials. In addition, functional disparities among strains and heterogeneity across clinical studies remain the core bottleneck in translating these fundamental findings into clinical practice.