文献类型：期刊文献

中文题名：当归补血汤化学成分、药理作用、临床应用的研究进展及质量标志物的预测分析

英文题名：Review of chemical constituents,pharmacological effects and clinical applications of Danggui Buxue Decoction and prediction and analysis of its Q-markers

作者：杨飞霞[1];王玉[1];夏鹏飞[1,2,3];杨蕊菁[1,4];王玉霞[1];张建[1];樊秦[1];赵磊[1,2,3]

第一作者：杨飞霞

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学甘肃省高校中藏药化学与质量研究省级重点实验室,甘肃兰州730000;[3]甘肃省道地药材质量标准化技术研究与推广工程实验室,甘肃兰州730000;[4]庆阳市妇女儿童医院,甘肃庆阳745000

第一机构：甘肃中医药大学

年份：2021

卷号：46

期号：11

起止页码：2677

中文期刊名：中国中药杂志

外文期刊名：China Journal of Chinese Materia Medica

收录：CSTPCD;;Scopus;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；PubMed;

基金：国家自然科学基金项目(81660577);甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金项目(ddyc-2016-04);甘肃省中医药管理局科研项目(G2K-2014-77)。

语种：中文

中文关键词：当归补血汤;化学成分;药理作用;临床应用;质量标志物

外文关键词：Danggui Buxue Decoction;chemical constituents;pharmacological effects;clinical application;Q-marker

摘要：当归补血汤为经典的气血双补名方,主治老疲内伤、气弱血虚、阳浮外越。现代药理学研究表明其具有促进造血、调节免疫、保护心脑血管等作用,临床多用于治疗多种原因所致之贫血等血液系统疾病、心脑血管系统疾病及肿瘤等。该方由黄芪一两、当归二钱组成,芪归用量为5∶1,是现代复方研究补气生血的代表方剂。该文在对当归补血汤的化学成分、药理作用及临床应用研究近况进行综述的基础上,结合中药质量标志物"五原则"——传递与溯源、特有性、有效性、可测性及复方配伍环境对当归补血汤的质量标志物(Q-marker)进行预测分析。结果提示毛蕊异黄酮、毛蕊异黄酮葡萄糖苷、芒柄花素、芒柄花苷、黄芪甲苷、阿魏酸、藁本内酯可作为当归补血汤的Q-marker,为后续建立完整的当归补血汤质量体系提供参考。
Danggui Buxue Decoction is a classic prescription of Qi and blood tonification, which is mainly applied in treating fatigue, internal damage Qi weakness, blood deficiency, and outward going of floating Yang. Modern pharmacology shows that it can promote hematopoiesis, regulate immunity, and protect heart and cerebral vessels. The prescription, often used for the treatment of anemia and other diseases in clinic, is composed of Astragali Radix and Angelicae Sinensis Radix at a dosage ratio of 5∶1. It is a modern compound prescription for invigorating Qi and generating blood. Based on the review of the chemical constituents, pharmacological effects, and clinical applications of Danggui Buxue Decoction, its Q-marker was predicted and analyzed according to the "five principles" of Chinese medicine Q-marker--quality transmissibility and traceability, ingredient specificity, component validity, component measurabi-lity, and formula compatibility environment. The results suggested that calycosin, calycosin-7-O-β-D-glucoside, formononetin, ononin, astragaloside A, ferulic acid, and ligustilide could be used as Q-markers of Danggui Buxue Decoction, which provides reference for establishing the quality system of Danggui Buxue Decoction.