文献类型：期刊文献

中文题名：红芪有效成分抗肿瘤作用及机制研究进展

英文题名：Anti-tumor Effect and Mechanism of Effective Components in Hedysari Radix:A Review

作者：贾妙婷[1];李成义[1];强正泽[1];王明伟[1];冯晓莉[1];魏小成[1];周瑞娟[1];张广袤[1]

第一作者：贾妙婷

机构：[1]甘肃中医药大学,兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：29

期号：21

起止页码：213

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金地区基金项目(82160730);国家自然科学基金青年科学基金项目(82104345);甘肃省教育厅双一流重大科研项目(GSSYLXM-05);甘肃省优秀博士生项目(22JR5RA575);甘肃省重点研发计划项目(21YF5FA133)。

语种：中文

中文关键词：红芪;有效成分;抗肿瘤;作用机制;研究进展

外文关键词：Hedysari Radix;active components;anti-tumor;mechanism;research progress

摘要：恶性肿瘤是全球范围人类死亡的主要原因之一,严重威胁人类健康,目前的治疗方法主要为化疗药物、手术、放疗或激素治疗的组合,其治疗过程存在多药耐药、癌细胞非选择性靶向、药物毒性等局限性。随着中医药的发展和应用,发现中药具有多角度、多机制协同、不良反应小的特点,能有效抑制肿瘤增殖、分化和转移,可避免产生耐药性,是当前肿瘤治疗研究的焦点。红芪是甘肃道地药材之一,为补益类中药,具有抗炎、免疫调节、抗氧化、防治糖尿病并发症等广泛的药理作用,历代本草中多将红芪列入黄芪项下,作为黄芪使用,红芪在增强免疫力、清除自由基活性、抗肝纤维化方面要优于黄芪。研究发现,红芪有效成分抗肿瘤作用突出,对肝癌、膀胱癌、胃癌、乳腺癌、结肠癌等多种恶性肿瘤具有显著抑制作用,还可联合临床抗癌药物,降低化疗药的不良反应,提高患者化疗过程的耐受性。在目前研究基础上,对红芪有效成分诱导细胞凋亡、阻滞细胞周期、抑制肿瘤细胞增殖、迁移与侵袭、调控微小mRNA(miRNA)、诱导细胞自噬、增强免疫调节作用及联合临床化疗药减毒增效、增敏作用的机制进行总结归纳,系统阐释红芪有效成分抗肿瘤作用机制,为红芪抗肿瘤作用机制的深入探讨和有效成分的进一步开发利用提供基础参考。
Malignant tumors are one of the main causes of human death worldwide and pose a serious threat to human health.The current treatment methods are mainly the combination of chemotherapeutics,surgery,radiotherapy,or hormone therapy.The treatment process has limitations such as multidrug resistance,non-selective targeting of cancer cells,and drug toxicity.With the development and application of traditional Chinese medicine(TCM),Chinese medicine has the characteristics of multi-angle and multi-mechanism coordination and slight toxic and side effects.It can effectively inhibit tumor proliferation,differentiation,and metastasis,and avoid drug resistance,serving as the focus of current tumor treatment research.Hedysari Radix,one of the genuine medicinal materials in Gansu province,is a tonic Chinese medicine with a wide range of pharmacological effects such as anti-inflammation,immune regulation,anti-oxidation,prevention and treatment of diabetic complications.In the majority of the ancient works on herbs of the past dynasties,Hedysari Radix was included under the item of Astragali Radix and used as Astragali Radix.Hedysari Radix is superior to Astragali Radix in enhancing immunity,scavenging free radicals,and resisting liver fibrosis.Studies have found that the effective components of Hedysari Radix have a prominent anti-tumor effect and a significant inhibitory effect on various malignant tumors such as liver cancer,bladder cancer,gastric cancer,breast cancer,and colorectal cancer.They can also combine with clinical anti-cancer drugs to reduce the toxic and side effects of chemotherapy drugs and improve the tolerance of patients during chemotherapy.On the basis of current research,this study summarized the mechanism of Hedysari Radix active components in inducing cell apoptosis,blocking cell cycle,inhibiting tumor cell proliferation,migration,and invasion,regulating micro mRNA(miRNA),inducing cell autophagy,enhancing immune regulation,as well as reducing toxicity and enhancing efficiency and sensitization with clinical chemotherapeutics,and systematically explained the anti-tumor mechanism of Hedysari Radix active components,aiming to provide a basic reference for the further exploration of the anti-tumor mechanism of Hedysari Radix and the further development and utilization of its effective components.