文献类型：期刊文献

英文题名：The Role of Traditional Chinese Medicine in Acute Lung Injury: Targeting Programmed Cell Death

作者：Hao, Guoxiong[1];Wang, Guanwei[1];Liang, Xiali[1];Xu, Qian[2];Han, Bingge[2];Li, Fu[2];Guo, Shuming[2];Zhang, Zhiming[2]

第一作者：Hao, Guoxiong

通信作者：Guo, SM[1];Zhang, ZM[1]

机构：[1]Gansu Univ Chinese Med, Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Dept Crit Care Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Crit Care Med, Lanzhou, Gansu, Peoples R China.

年份：2026

卷号：20

外文期刊名：DRUG DESIGN DEVELOPMENT AND THERAPY

收录：;Scopus(收录号：2-s2.0-105049553205);WOS:【SCI-EXPANDED(收录号:WOS:001865438500001)】；

基金：This work was supported by National Natural Science Foundation of China Grant (82460925); Gansu Province "Silver-Age Experts Studio" Project (Provincial Party Committee Talent Group Document [2025] No. 4); 2024 Gansu Provincial Traditional Chinese Medicine Research Project (GZKZ-2024-2) Figures were rendered using Figdraw (www.figdraw.com) .

语种：英文

外文关键词：acute lung injury; programmed cell death; traditional Chinese medicine; molecular mechanisms

摘要：Acute lung injury (ALI) is a critical clinical condition with high mortality and morbidity. It initially manifests as hypoxemia, pulmonary interstitial edema, and pulmonary inflammation, and may progress to acute respiratory distress syndrome, posing a serious threat to human health. Conventional treatments have certain limitations, underscoring the urgent need for new therapeutic strategies. Traditional Chinese Medicine (TCM), with its advantages of low cost, low risk of drug resistance, and fewer adverse effects, has accumulated extensive experience in ALI treatment through its multi-component, multi-target, and multi-pathway regulatory effects. Research has shown that various TCM-derived active compounds from plants, animals, or microorganisms can effectively regulate programmed cell death (PCD), thereby reducing inflammatory responses, suppressing oxidative stress, and ameliorating ALI-induced lung tissue damage. Against this backdrop, this review aims to elucidate the mechanisms by which traditional Chinese medicine improves ALI by regulating individual and interacting PCD pathways, and to systematically evaluate the impact of existing evidence and barriers to translation on the clinical application potential of this therapeutic strategy. Based on a systematic literature search in databases including PubMed, Web of Science, Science Direct, and Google Scholar for studies published up to December 2025, this review comprehensively summarizes the pharmacological actions, mechanisms, efficacy, and safety of TCM with PCD-regulating functions, and proposes a novel TCM-PCD-ALI regulatory axis, aiming to fill the current gap in understanding the relationship between PCD and ALI, provide more treatment options for patients with ALI, and advance the development of therapeutic strategies in this field.