详细信息
细胞程序性死亡在金黄色葡萄球菌感染中的研究进展 被引量:1
Advances in Programmed Cell Death in Staphylococcus aureus Infection
文献类型:期刊文献
中文题名:细胞程序性死亡在金黄色葡萄球菌感染中的研究进展
英文题名:Advances in Programmed Cell Death in Staphylococcus aureus Infection
作者:吴志航[1,2,3];潘海邦[1];荣耀[1];唐明政[1];崔岩[1,2,3];王天明[1,2,3]
第一作者:吴志航
机构:[1]甘肃中医药大学第一临床医学院,兰州730000;[2]甘肃省中药新产品创制工程实验室,兰州730000;[3]甘肃省中医方药挖掘与创新转化重点实验室,兰州730000
第一机构:甘肃中医药大学临床医学院
年份:2023
卷号:43
期号:11
起止页码:66
中文期刊名:中国生物工程杂志
外文期刊名:China Biotechnology
收录:CSTPCD;;Scopus;北大核心:【北大核心2020】;CSCD:【CSCD2023_2024】;
基金:国家自然科学基金(81860850);甘肃省高等学校创新基金(2023A-076);甘肃中医药大学硕士研究生创新创业基金(20号)资助项目。
语种:中文
中文关键词:细胞程序性死亡;金黄色葡萄球菌;凋亡;焦亡;自噬;铁死亡
外文关键词:Programmed cell death(PCD);Staphylococcus aureus;Apoptosis Pyroptosis;Autophagy;Ferroptosis
摘要:细胞程序性死亡(PCD)是细胞受到内在调控死亡的统称,是在生物体生长发育以及对环境和疾病作出应激反应过程中,通过自身程序性调控而引起的不同形式的细胞死亡。PCD包括细胞凋亡、焦亡、坏死性凋亡、自噬、铁死亡等。PCD不仅对生物体的生长发育至关重要,而且对于病原体入侵起重要干预作用。金黄色葡萄球菌在宿主体内能够调控细胞凋亡、焦亡、坏死性凋亡及自噬等多种PCD形式,进而影响细菌感染。综述了金黄色葡萄球菌感染与PCD之间的作用串扰,探讨了金黄色葡萄球菌与细胞死亡之间的关系,以期为临床金黄色葡萄球菌感染疾病的诊疗提供新思路。
Programmed cell death(PCD)is a collective term for the intrinsically regulated death of cells.Different forms of cell death are caused by their own programmed regulation during the growth and development of organisms and stress responses to the environment and diseases.PCD includes apoptosis,pyroptosis,necroptosis,autophagy and ferroptosis.It is not only essential for the growth and development of organisms,but also plays an important role in intervening in the process of pathogens invasion.Staphylococcus aureus can regulate various forms of PCD such as apoptosis,pyroptosis,necroptosis and autophagy in host cells,thereby affecting bacterial infection.This article reviews the crosstalk between Staphylococcus aureus infection and PCD to further understand the relationship between Staphylococcus aureus and cell death,in order to provide new ideas for the diagnosis and treatment of clinical Staphylococcus aureus infection.
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