文献类型：期刊文献

英文题名：Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology

作者：Yang F.; Dong X.; Yin X.; Wang W.; You L.; Ni J.

第一作者：Yang F.

机构：[1]Gansu University of Chinese Medicine, Lanzhou, 730000, China;[2]School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China

第一机构：甘肃中医药大学

通信机构：[1]Gansu University of Chinese Medicine, Lanzhou, 730000, China|[10735]甘肃中医药大学;

年份：2017

卷号：2017

外文期刊名：BioMed Research International

收录：Scopus(收录号：2-s2.0-85020026923)

语种：英文

摘要：Radix Bupleuri (Chaihu) has been used as a traditional medicine for more than 2000 years in China, Japan, Korea, and other Asian countries. Phytochemical studies demonstrated that this plant contains essential oils, triterpenoid saponins, polyacetylenes, flavonoids, lignans, fatty acids, and sterols. Crude extracts and pure compounds isolated from Radix Bupleuri exhibited various biological activities, such as anti-inflammatory, anticancer, antipyretic, antimicrobial, antiviral, hepatoprotective, neuroprotective, and immunomodulatory effects. However, Radix Bupleuri could also lead to hepatotoxicity, particularly in high doses and with long-term use. Pharmacokinetic studies have demonstrated that the major bioactive compounds (saikosaponins a, b2, c, and d) were absorbed rapidly in rats after oral administration of the extract of Radix Bupleuri. This review aims to comprehensively summarize the traditional uses, botany, phytochemistry, pharmacology, toxicology, and pharmacokinetics of Radix Bupleuri reported to date with an emphasis on its biological properties and mechanisms of action. ? 2017 Fude Yang et al.