文献类型：期刊文献

英文题名：Review Article The role and research progress of tumor-associated macrophages in cervical cancer

作者：Wang, Dan[1];Han, Xue[2];Liu, Hui-Ling[2]

第一作者：王丹

通信作者：Liu, HL[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll, Dept 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Peoples Hosp, Dept Gynecol, 204 Donggang West Rd, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学临床医学院

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Dept Gynecol, 204 Donggang West Rd, Lanzhou, Gansu, Peoples R China.

年份：2024

卷号：14

期号：12

起止页码：5999

外文期刊名：AMERICAN JOURNAL OF CANCER RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001406535800029)】；

基金：The present study was supported by a grant from the National Natural Science Foundation of China (grant No. 82260557) and New Cancer Supportive Treatment Research Project of Education (cphcf-2022-012) .

语种：英文

外文关键词：Cervical cancer; tumor microenvironment; tumor-associated macrophages; polarization; immunotherapy

摘要：Tumor-associated macrophages (TAMs) are important immune cells in the tumor micro-environment (TME) and play a key role in the occurrence and development of cervical cancer. Besides, targeting TAMs can significantly inhibit cervical cancer tumor growth, invasion, metastasis, and angiogenesis as well as affect immune regulation. This review summarizes the correlation between TAM and tumors, the mechanism of action of TAM in cervical cancer, and the potential application of TAM in the treatment of cervical cancer. Therefore, this study may provide new ideas and targets for the development of further treatment strategies for cervical cancer patients.