文献类型：期刊文献

中文题名：肠道菌群在老年慢性阻塞性肺疾病合并肌少症中的机制探讨

英文题名：Study on the Mechanism of Intestinal Microflora in Elderly Patients with Chronic Obstructive Pulmonary Disease Complicated with Sarcopenia

作者：马娇娇[1];夏晓黎[2];王亚锋[2];马艳萍[2];刘文慧[1]

第一作者：马娇娇

机构：[1]甘肃中医药大学中西医结合学院,甘肃兰州730000;[2]甘肃中医药大学附属医院老年病科,甘肃兰州730000

第一机构：甘肃中医药大学中西医结合学院

年份：2024

卷号：21

期号：4

起止页码：156

中文期刊名：中国医学创新

外文期刊名：Medical Innovation of China

基金：甘肃省中医药科研课题(G21cp-2022-19);兰州市科技局发展计划项目(2022-ZD-86)。

语种：中文

中文关键词：老年;慢性阻塞性肺疾病;肌少症;肠道菌群

外文关键词：Elderly;Chronic obstructive pulmonary disease;Sarcopenia;Intestinal flora

摘要：肌少症在老年慢性阻塞性肺疾病人群中患病率较高,与慢性阻塞性肺疾病密切相关。两者共存不仅损害患者身心健康,还增加了临床治疗的难度。现代医学对慢性阻塞性肺疾病合并肌少症的发病机制研究较少,临床治疗也以对症处理为主,以缓解症状、减少COPD急性发作次数为目的。对于老年慢性阻塞性肺疾病和肌少症临床共病之间可能存在内在联系,但目前对该合并症关注不足。随着生物技术的不断进步,肠道菌群的作用在许多慢性疾病的发病机制中越来越受到重视。有研究表明,老年慢性阻塞性肺疾病患者肠道菌群存在明显失衡,而肌少症的发生也与肠道菌群关系较为密切。本文通过探讨肠道菌群与老年慢性阻塞性肺疾病合并肌少症之间的相互关系,分析肠道菌群的失衡可能是导致老年慢性阻塞性肺疾病合并肌少症的关键因素之一,提出以微生态疗法调节肠道菌群失衡,可能成为临床防治老年慢性阻塞性肺疾病合并肌少症的一种新途径。
Sarcopenia is high in the prevalence of chronic obstructive pulmonary disease in the elderly,which is closely related to chronic obstructive pulmonary disease.The coexistence of the two not only harms the physical and mental health of patients,but also increases the difficulty of clinical treatment.Modern medicine has less pathogenic mechanisms for chronic obstructive pulmonary diseases and sarcopenia.Clinical treatment is mainly based on symptomatic treatment,with the purpose of alleviating symptoms and reducing COPD acute seizures.There may be an intrinsic relationship between chronic obstructive pulmonary disease and sarcopenia in the elderly,but insufficient attention has been paid to this comorbidity.With the continuous advancement of biotechnology,the role of intestinal flora has become increasingly valued in the pathogenesis of many chronic diseases.Studies have shown that the intestinal flora in patients with chronic obstructive pulmonary diseases has obvious imbalances,and the occurrence of sarcopenia is also closely related to the intestinal flora.By exploring the interaction between the intestinal flora and the chronic obstructive pulmonary disease of the elderly,the analysis of the imbalance of the intestinal flora may be one of the key factors that cause chronic obstructive pulmonary disease in the elderly.It is proposed to regulate the imbalance of intestinal flora with micro-ecological therapy,which may become a new way to clinical prevention and treatment of chronic obstructive pulmonary disease and sarcopenia.