文献类型：期刊文献

英文题名：20 Hz tACS engages striatal THINs to enhance β-band synchrony and motor drive

作者：Zang, Honggang[1];Xie, Wanxia[2];Tian, Lei[1];Kang, Wanrong[3];Li, Yulan[1]

第一作者：Zang, Honggang

通信作者：Li, YL[1]

机构：[1]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Ultrasound Med, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China.

年份：2026

卷号：20

外文期刊名：FRONTIERS IN NEUROSCIENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001877760000001)】；

语种：英文

外文关键词：aging; anesthesia; motor function; tACS; THINs

摘要：Background Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation technique that can enhance motor function. The striatum is a central hub for motor control and beta-band oscillations, and its tyrosine hydroxylase-positive interneurons (THINs) are modulated by dopamine. However, whether THINs are associated with motor changes following tACS through beta-band synchrony has not been investigated.Methods Eighteen-month-old male mice received 20 Hz tACS or sham stimulation over M1 for 7 days under sevoflurane anesthesia. Motor performance, EEG, striatal dopamine release, and THIN activation were assessed at 3 min after awakening on day 7. THINs were optogenetically manipulated during the reaching task under the same post-anesthesia testing window.Results Transcranial alternating current stimulation was associated with higher post-anesthesia reaching success, increased beta-band power, elevated dopamine release, and enhanced THIN activation compared to sham. Optogenetic THIN activation recapitulated motor improvement and beta-band enhancement. Optogenetic THIN inhibition reduced successful attempts per minute and beta-band power, but no statistically significant reduction in success rate was detected.Conclusion These findings suggest that 20 Hz tACS over M1 may improve post-anesthesia motor performance in aged mice, with converging evidence implicating striatal dopamine release, THIN engagement, and beta-band synchrony as functionally coupled elements in the context of post-anesthesia motor recovery in aged mice.