文献类型：期刊文献

中文题名：基质金属蛋白酶-3基因启动子5A／6A多态性对高血压患者左室重构的影响

英文题名：Impact of the matrix metalloproteinase 3 promoter 5A/6A polymorphism on left ventricle hyper- trophy

作者：陆玉琴[1];马丽雅[2];何华[2];侯春霞[3]

第一作者：陆玉琴

机构：[1]兰州甘肃中医学院附属医院心血管内科,730000;[2]甘肃省人民医院干部病房心内科;[3]甘肃省人民医院干部超声科

第一机构：甘肃中医药大学第二附属医院

年份：2012

卷号：29

期号：10

起止页码：707

中文期刊名：临床内科杂志

外文期刊名：Journal of Clinical Internal Medicine

收录：CSTPCD

语种：中文

中文关键词：基质金属蛋白酶-3;基因多态性;左室重构;高血压病

外文关键词：Matrix metalloproteinase-3 ; Polymorphism; Left ventricular hypertrophy; Hypertension

摘要：目的探讨基质金属蛋白酶-3（MMP-3）基因启动子-1171（5A／6A）多态性对高血压患者左室重构的影响。方法采用限制性片段长度多态性分析技术，检测104例高血压病患者和36例对照者的MMP-3基因启动子-1171（5A／6A）基因型的表达，并且对并且对104例高血压患者和46例正常人进行超声心动图检查，计算左室重量（LVM）及左室重量指数（LVMI）。结果高血压病组与对照组MMP-3基因启动子-1171（5A／6A）基因型分布比较差异无统计学意义。高血压病组的LVM、LVMI水平与对照组比较，差异均有统计学意义（P〈0．05）。高血压病组内6A／6A基因型者的LVM、LVMI水平较5A／6A和5A／5A型高血压病患者升高，且两组女性患者LVMI水平比较差异有统计学意义（P〈0．05）。多因素方差分析及多元逐步回归分析显示，LVMI与患者高血压病程、脉压、6A／6A基因型等均有不同程度的相关。结论MMP-3基因启动子-1171（5A／6A）多态性对高血压病患者左室重构有影响。
Objective To investigate the possible impact of the polymorphism in 5A/6A Matrix metalloproteinase-3 （MMP-3） gene promoter on the risk of left ventricle hypertrophy Methods 104 hy- pertensives and 36 control subjects were recruited. Polymerase chain reaction followed by restrictionfrag- ment length polymorphism（PCR-RFLP） was used to detect SNP-1171 （5A/6A）in MMP-3 gene promoter region. LV mass （LVM） was calculated using theformula ： 0. 8 × （ 1.04 × [ （ LVIDd ＋ IVSd ＋ PWd） 3 _ （LVIDd） 3 ） ] ＋ 0.6. Left ventricular mass index （LVMI） was determined using formula： LVM/BSA, where BSA was the body surface area. Results The distribution of MMP-3 genotype was not significantly differ- ent between hypertensive patients and controls. LVMI were signnieantly higher in the subjects than con- trois. Genotype 6A/6A in hypertensives LVMI higher than 5A/6A and 5A/5A though males and females. When Univariate Stepwise Regression analysis was used, we found there increased risk for left ventricular remodling associated with course, pulse pressure and genotype 6A/6A in hypertensive patients than con- trois. Coneinsion These results indicate that there was differences in association of MMP-3 5A/6A poly- morphism with left ventrieular hypertrophy.