文献类型：期刊文献

中文题名：四神丸合理中汤联合美沙拉嗪治疗溃疡性结肠炎作用机制研究

英文题名：Study on the Mechanism of Sishen Pills,Lizhong Tang and Mesalazine in the Treatment of Ulcerative Colitis

作者：苏海燕[1];陈怀霞[1];陈晓彤[2];宋鹏[1]

第一作者：苏海燕

机构：[1]甘肃中医药大学附属医院,甘肃兰州730000;[2]临洮县中医院,甘肃临洮730500

第一机构：甘肃中医药大学第二附属医院

年份：2023

卷号：36

期号：1

起止页码：92

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：甘肃省自然科学基金(1508RJZA018)。

语种：中文

中文关键词：溃疡性结肠炎;辅助性T细胞22;白细胞介素22;四神丸;理中汤;美沙拉嗪

外文关键词：UC;Th22;IL-22;Sishen pills;Lizhong Tang;mesalazine

摘要：目的:探讨四神丸、理中汤联合美沙拉嗪治疗溃疡性结肠炎(ulcerative colitis,UC)的作用机制。方法:将UC患者162例使用随机数字表法分为对照组与联合组各81例。对照组予美沙拉嗪治疗,联合组予四神丸合理中汤联合美沙拉嗪治疗。记录两组患者治疗前及治疗3个月免疫功能指标{辅助性T细胞22(T helper cell 22,Th22)、辅助性T细胞17(T helper cell 17,Th17)、血清免疫球蛋白[免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白A(immunoglobulin A,IgA)]}、血清炎症因子[白细胞介素22(interleukin-22,IL-22)、白细胞介素17(interleukin-17,IL-17)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α)]、肠道菌群(肠球菌、乳酸菌、双歧杆菌、大肠杆菌)、血流动力学参数[红细胞压积(packed cell volume,PCV)、血浆黏度(plasma viscosity,PV)]水平,观察两组患者不良反应发生情况。结果:治疗3个月,两组患者免疫功能指标(Th22、Th17、IgG、IgA)、炎症因子(IL-22、IL-17、TNF-α)、血流动力学参数(PCV、PV)、粪便中大肠杆菌水平低于治疗前(P<0.05),联合组低于对照组(P<0.05);乳酸菌、双歧杆菌高于治疗前(P<0.05),联合组高于对照组(P<0.05)。肠球菌联合组高于治疗前与治疗后对照组(P<0.05),对照组与治疗前比较差异无统计学意义(P>0.05)。两组患者治疗后不良反应发生率比较差异无统计学意义(P>0.05)。结论:四神丸合理中汤联合美沙拉嗪有助于提高UC患者免疫功能,减轻患者肠道炎症反应。
Objective:To explore the mechanism of Sishen pills,Lizhong Tang and mesalazine in treating UC.Methods:All 162 UC patients were allocated to the control group and the combination group by using random number table method,with 81 cases in each group.The control group was treated by mesalazine,and the combination group by Sishen pills,Lizhong Tang and mesalazine.To record the indexes of immune function[(Th22,Th17),serum immunoglobulin(IgG,IgA)],serum inflammatory factors(IL-22,IL-17 and TNF-α),intestinal flora(enterococcus,lactobacillus,bifidobacterium and colibacillus),as well as the levels of hemodynamic parameters(PCV and PV)before treating and three months after the treatment between both groups,to observe the incidence of adverse reaction between both groups.Results:Three months after the treatment,the levels of the indexes of immune function(Th22,Th17,IgG and IgA),serum inflammatory factors(IL-22,IL-17and TNF-α),hemodynamic parameters(PCV and PV)and the levels of colibacillus in the excrement of both groups were lower than these before treating(P<0.05),the combination group was lower than the control group(P<0.05),the levels of lactobacillus and bifidobacterium were higher than these before treatment(P<0.05),the combination group was higher than the control group(P<0.05).The levels of enterococcus of the combination group were higher than these before treatment,and the control group after the treatment(P<0.05),the difference had no statistical meaning when the control group was compared with that before treatment(P>0.05).The difference had no statistical meaning in the incidence of adverse reaction between both groups after the treatment(P>0.05).Conclusion:Sishen pills,Lizhong Tang and mesalazine could help UC patients’immune function and relieve intestinal inflammatory reaction.