文献类型：期刊文献

中文题名：岷县当归预适应对大鼠缺血-再灌注心律失常的影响

英文题名：Effects of MinXian County Angelica Pre-adaptation to the Rats with Ischemia-Reperfusion Arrhythmia

作者：陈彦文[1];明海霞[1];王强[1];赵鹏[1];郭超[1];赵英[1]

第一作者：陈彦文

机构：[1]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2013

卷号：26

期号：2

起止页码：15

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

基金：甘肃省教育厅基金项目(编号044B-03)

语种：中文

中文关键词：岷县当归;T波电压;心电图;心率;心律失常;再灌注

外文关键词：MinXian county angelica; T wave voltage, ECG; heart rate; arrhythmia, reperfusion

摘要：目的:观察岷县当归预适应对大鼠心肌缺血-再灌注心律失常的保护作用。方法:腹腔注射垂体后叶素和硝酸甘油复制I/R模型,统计分析模型大鼠再灌注前后T波电压、心率变化及室性心律失常的发生率。结果:岷县当归预适应能有效降低模型大鼠T波电压的抬高程度,稳定心率,减少或防止大鼠心肌缺血再灌注室性心律失常的发生。结论:岷县当归预适应可减少或防止大鼠再灌注室性心律失常的发生,从而减轻再灌注性心肌损伤,对心肌缺血再灌注后大鼠心功能具有明显保护作用。
Objective： To observe the protection of MinXian County Angelica pre-adaptation to the rats with ischemia-reperfusion arrhythmia. Method：I/R models were established through injecting hypophysin and glyceryl trinitrate to abdominal cavity. The incidence of ventricular arrhythmia, changes of heart rate and T wave voltage in rats were analyzed statistically before and after reperfusion. Result： The pre-adaptation of MinXian County Angelica could effectively decrease the raise ofT wave voltage in rat models, maintain steady heart rate and reduce or prevent the incidence ofischemia-reperfusion arrhythrnia in rats. Conclusion： The pre-adaptation of MinXian County angelica could reduce or prevent the incidence of reperfusion arrhythmia in rats to alleviate myocardial damage due to reperfusion and it shows the protection to heart function of rats with myocardial ischemia-reperfusion.